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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-496 品牌系列 Upstate
商名 - Upstate
描述 Anti-Myeloperoxidase Antibody 产品信息 格式 Serum 演示 0.05% sodium azide and 30% glycerol 应用 应用 Anti-Myeloperoxidase Antibody detects level of Myeloperoxidase & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Purified protein from human neutrophil granules 宿主 Rabbit 特异性 myeloperoxidase subunits and glycosylated precursor 同种型 IgG 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000250
Entrez基因汇总 Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. 基因符号 - myeloperoxidase
- MPO
纯化方法 Antiserum UniProt编号 - P05164
UniProt汇总 FUNCTION: SwissProt: P05164 # Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
COFACTOR: Binds 1 calcium ion per heterodimer. & Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.
SIZE: 745 amino acids; 83869 Da
SUBUNIT: Tetramer of two light chains and two heavy chains.
SUBCELLULAR LOCATION: Lysosome.
DISEASE:SwissProt: P05164 # Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
SIMILARITY: SwissProt: P05164 ## Belongs to the peroxidase family. XPO subfamily.产品使用声明 质量保证 routinely evaluated by immunoblot in RIPA lysates from HL-60 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µL
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