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经验配方 CAS号 C₈H₁₂N₄O₄ 2353-33-5 描述 概述 A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. Also available as a 100 mM solution in DMSO (Cat. No. 189826). 产品目录编号 189825 品牌系列 Calbiochem®
同义词 5-Aza-CdR, 5-Aza-dC, 2'-Deoxy-5-azacytidine, Decitabine 参考 参考 Eggert, A., et al. 2001. Cancer Res. 61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
Haaf, T. 1995. Pharmacol. Ther. 65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.产品信息 CAS号 2353-33-5 形式 Lyophilized Hill配方 C₈H₁₂N₄O₄ 化学配方 C₈H₁₂N₄O₄ Molar Mass 228.2 结构配方图像 生物信息 主靶 DNA methyltransferase inhibitor 纯度 ≥ 98% by HPLC 理化信息 溶解度 MeOH, DMSO, or 50% Acetic Acid GHS安全信息 RTECS XZ3012000 安全信息 R相 R: 20/21/22-36/37/38-43-61
Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
May cause sensitization by skin contact.
May cause harm to the unborn child.S相 S: 22-26-36/37/39-45
Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful & Carcinogenic / Teratogenic
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,448103,Met/Flt-3/VEGFR2 Tyrosine Kinase Inhibitor - CAS 888719-03-7 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,118500,ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem
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