merck millipore,默克密理愽
  • merck millipore,默克密理博,197220,Bcl-2 Binding Peptide, Cell-Permeable - Calbiochem

  • merck millipore,默克密理博,197220,Bcl-2 Binding Peptide, Cell-Permeable - Calbiochem

    产品名称：Bcl-2 Binding Peptide, Cell-Permeable - Calbiochem
    产品型号：197220
    A cell-permeable peptide that binds to Bcl-2 with high affinity (IC₅₀ = 130 nM in a competition binding study) and induces apoptosis.

    merck millipore,默克密理博,197220,Bcl-2 Binding Peptide, Cell-Permeable - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,197220,Bcl-2 Binding Peptide, Cell-Permeable - Calbiochem

    重要规格表

    经验配方
    C₁₅₃H₂₄₀N₄₄O₄₂S
    描述
    概述 A cell-permeable peptide that binds to Bcl-2 with high affinity (IC50 = 130 nM in a competition binding study) and induces apoptosis. Displays antitumor activity in cells overexpressing Bcl-2 with no apparent effect on normal peripheral lymphocytes. The peptide is derived from the BH3 domain (residues 140 - 165, a “death domain”) of Bad and is modified to be cell permeant by attaching a decanoyl moiety at the N-terminus.
    产品目录编号 197220
    品牌系列 Calbiochem®
    同义词 cpm-1285, Decanoyl-KN¹⁴⁰LWAAQRYGRELRRMSDEFEGSFKGL¹⁶⁵-OH
    参考
    参考 Wang, J-L., et al. 2000. Cancer Res. 60, 1498.
    Kelekar, A., et al. 1997. Mol. Cell. Biol. 17, 7040.
    产品信息
    具有ATP竞争性 N
    形式 Off-white solid
    配方 Supplied as a trifluoroacetate salt.
    Hill配方 C₁₅₃H₂₄₀N₄₄O₄₂S
    化学配方 C₁₅₃H₂₄₀N₄₄O₄₂S
    Molar Mass 3399.9
    吸湿 Hygroscopic
    肽序列 CH₃(CH₂)₈CONH-Lys-Asn-Leu-Trp-Ala-Ala-Gln-Arg-Tyr-Gly-Arg-Glu-Leu-Arg-Arg-Met-Ser-Asp-Glu-Phe-Glu-Gly-Ser-Phe-Lys-Gly-Leu-OH
    可逆 N
    生物信息
    主靶 Bcl-2
    主靶IC50 130 nM against Bcl-2
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    肽序列 CH₃(CH₂)₈CONH-Lys-Asn-Leu-Trp-Ala-Ala-Gln-Arg-Tyr-Gly-Arg-Glu-Leu-Arg-Arg-Met-Ser-Asp-Glu-Phe-Glu-Gly-Ser-Phe-Lys-Gly-Leu-OH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 weeks at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,197220,Bcl-2 Binding Peptide, Cell-Permeable - Calbiochem

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