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merck millipore,默克密理博,118500,ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem
产品名称：ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem
产品型号：118500
The ATM Kinase Inhibitor, also referenced under CAS 587871-26-9, controls the biological activity of ATM Kinase. This small molecule/inhibitor is primarily used for Cell Structure applications.
merck millipore,默克密理博,118500,ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₁H₁₇NO₃S₂ 587871-26-9 描述 概述 A cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5 , 9.3 , 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 = µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents. A 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118502) in DMSO is also available. 产品目录编号 118500 品牌系列 Calbiochem®
同义词 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933 参考 参考 Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
Hickson, I., et al. 2004. Cancer Res. 64, 9152.产品信息 CAS号 587871-26-9 具有ATP竞争性 Y 形式 White solid Hill配方 C₂₁H₁₇NO₃S₂ 化学配方 C₂₁H₁₇NO₃S₂ Molar Mass 395.5 可逆 N 结构配方图像 生物信息 主靶 ATM Kinase 主靶IC50 13 nM 主靶Ki 2.2 nM for ATM kinase 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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