merck millipore,默克密理愽
  • merck millipore,默克密理博,182541,Aromatase Inhibitor II, Letrozole - CAS 112809-51-5 - Calbiochem

  • merck millipore,默克密理博,182541,Aromatase Inhibitor II, Letrozole - CAS 112809-51-5 - Calbiochem

    产品名称：Aromatase Inhibitor II, Letrozole - CAS 112809-51-5 - Calbiochem
    产品型号：182541
    The Aromatase Inhibitor II, Letrozole, also referenced under CAS 112809-51-5, controls the biological activity of Aromatase.

    merck millipore,默克密理博,182541,Aromatase Inhibitor II, Letrozole - CAS 112809-51-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,182541,Aromatase Inhibitor II, Letrozole - CAS 112809-51-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₇H₁₁N₅112809-51-5
    描述
    概述 An orally bioavailable non-steroidal triazole compound that acts as a potent and selective inhibitor of aromatase (IC50 = 140, 350 and 450 pM in Dex-treated fibroblasts, MCF-7Ca, and JEG-3 cells, respectively). Competitively, but reversibly binds to the heme iron of aromatase. Does not affect the synthesis of adrenal mineralocorticoid or glucocorticoids. Reported to be highly effective as an anti-estrogenic and anti-proliferative agent in estrogen-rich tumors. Also delays the fusing of the growth plates in adolescents and enhances the effectiveness of growth hormone. Shown to synergistically induce apoptosis and cause tumor regression when combined with IGF-1R inhibitors.
    产品目录编号 182541
    品牌系列 Calbiochem®
    同义词 4,4ʹ-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile, 1-(bis-(4-Cyanophenyl)methyl)-1,2,4-triazole
    参考
    参考 Hou, X., et al. 2011. Cancer Res. 71, 7597.
    Lisztwan, J., et al. 2008. Breast Cancer Res. 10, R56.
    Miller, W.R., et al. 2002. Cancer Invest. 20 (Suppl 2), 15.
    Long, B.J., et al. 1998. J. Steroid Biochem. Molec. Biol. 67, 293.
    产品信息
    CAS号 112809-51-5
    形式 White powder
    Hill配方 C₁₇H₁₁N₅
    化学配方 C₁₇H₁₁N₅
    Molar Mass 285.3
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,182541,Aromatase Inhibitor II, Letrozole - CAS 112809-51-5 - Calbiochem

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