merck millipore,默克密理愽
  • merck millipore,默克密理博,16-308,Anti-Myc Tag Antibody, clone 9E10, Alexa Fluor 488 conjugate

  • merck millipore,默克密理博,16-308,Anti-Myc Tag Antibody, clone 9E10, Alexa Fluor 488 conjugate

    产品名称：Anti-Myc Tag Antibody, clone 9E10, Alexa Fluor 488 conjugate
    产品型号：16-308
    This Anti-Myc Tag Antibody, clone 9E10, Alexa Fluor 488 conjugate is validated for use in WB, IC for the detection of Myc Tag.

    merck millipore,默克密理博,16-308,Anti-Myc Tag Antibody, clone 9E10, Alexa Fluor 488 conjugate

  • 产品介绍
  • merck millipore,默克密理博,16-308,Anti-Myc Tag Antibody, clone 9E10, Alexa Fluor 488 conjugate

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    AICC, WBMAlexaFluor®488Monoclonal Antibody
    描述
    产品目录编号 16-308
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Myc Tag Antibody, clone 9E10, Alexa Fluor® 488 conjugate
    产品信息
    格式 AlexaFluor®488
    应用
    应用 This Anti-Myc Tag Antibody, clone 9E10, Alexa Fluor 488 conjugate is validated for use in WB, IC for the detection of Myc Tag.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    生物信息
    免疫原品种 Synthetic peptide corresponding to amino acids 408-437 of the Leucine zipper region of human Myc (AEEQKLISEEDLLRKRREQLKHKLEQ-LRNS)
    克隆 clone 9E10
    宿主 Mouse
    特异性 Myc and recombinant proteins containing the Myc epitope tag
    同种型 IgG1
    品种反应性 All
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002467.3
    Entrez基因汇总 The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
    基因符号
    • c-Myc
    • MYC
    • C-MYC
    纯化方法 Protein G purfied
    UniProt编号
    • P01106
    UniProt汇总 FUNCTION: SwissProt: P01106 # Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
    SIZE: 439 amino acids; 48804 Da
    SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with JARID1A and JARID1B.
    SUBCELLULAR LOCATION: Nucleus.
    PTM: Phosphorylated by PRKDC.
    DISEASE: SwissProt: P01106 # Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. & A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
    SIMILARITY: SwissProt: P01106 ## Contains 1 basic helix-loop-helix (bHLH) domain.
    产品使用声明
    质量保证 routinely evaluated by immunocytochemistry on myc-tagged recombinant protein
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
    储存和货运信息
    存储条件 1 year at 4°C from date of shipment
    包装信息
    数量 100 µg

    merck millipore,默克密理博,16-308,Anti-Myc Tag Antibody, clone 9E10, Alexa Fluor 488 conjugate

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