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品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 05-880 品牌系列 Upstate
商名 - Upstate
描述 Anti-Thrombin Antibody, clone GMA-020 产品信息 格式 Purified 应用 应用 Anti-Thrombin Antibody, clone GMA-020 is an antibody against Thrombin for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 purified human thrombin 克隆 GMA-020 宿主 Mouse 特异性 thrombin 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000506
Entrez基因汇总 Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. 基因符号 - PT
- F2
- prothrombin
纯化方法 DEAE purified UniProt编号 - P00734
UniProt汇总 FUNCTION: SwissProt: P00734 # Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C.
SIZE: 622 amino acids; 70037 Da
SUBCELLULAR LOCATION: Secreted, extracellular space.
TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.
PTM: The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin.
DISEASE: SwissProt: P00734 # Defects in F2 are the cause of various forms of dysprothrombinemia [MIM:176930]. & Genetic variations in F2 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
SIMILARITY: SwissProt: P00734 ## Belongs to the peptidase S1 family. & Contains 1 Gla (gamma-carboxy-glutamate) domain. & Contains 2 kringle domains. & Contains 1 peptidase S1 domain.
MISCELLANEOUS: Prothrombin is activated on the surface of a phospholipid membrane that binds the amino end of prothrombin and factors Va and Xa in Ca-dependent interactions; factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. The activation process starts slowly because factor V itself has to be activated by the initial, small amounts of thrombin. & It is not known whether 1 or 2 smaller activation peptides, with additional cleavage after Arg-314, are released in natural blood clotting. & Thrombin can itself cleave the N-terminal fragment (fragment 1) of the prothrombin, prior to its activation by factor Xa. & The cleavage after Arg-198, observed in vitro, does not occur in plasma.产品使用声明 质量保证 routinely evaluated by immunoblot on human thrombin 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 stable 2 years at -20°C from date of shipment 包装信息 数量 100 µg
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