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merck millipore,默克密理博,16-251,Anti-phospho-Histone H2B (Ser14) Antibody, clone MC603, FITC conjugate, rabbit monoclonal
产品名称：Anti-phospho-Histone H2B (Ser14) Antibody, clone MC603, FITC conjugate, rabbit monoclonal
产品型号：16-251
Anti-phospho-Histone H2B (Ser14) Antibody, clone MC603, FITC conjugate is a rabbit monoclonal antibody for detection of phospho-Histone H2B (Ser14) also known as H2BS14P, Histone H2B (phospho S14) & h More>>
merck millipore,默克密理博,16-251,Anti-phospho-Histone H2B (Ser14) Antibody, clone MC603, FITC conjugate, rabbit monoclonal
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- merck millipore,默克密理博,16-251,Anti-phospho-Histone H2B (Ser14) Antibody, clone MC603, FITC conjugate, rabbit monoclonal
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC Rb FITC Monoclonal Antibody 描述 产品目录编号 16-251 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-Histone H2B (Ser14) Antibody, clone MC603, FITC conjugate, rabbit monoclonal Alternate Names - Histone H2B (phospho S14)
- H2BS14P
产品信息 格式 FITC 应用 应用 Anti-phospho-Histone H2B (Ser14) Antibody, clone MC603, FITC conjugate is a rabbit monoclonal antibody for detection of phospho-Histone H2B (Ser14) also known as H2BS14P, Histone H2B (phospho S14) & has been validated in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 KLH-conjugated synthetic peptide containing the sequence KGpSK in which pS corresponds to phospho-serine 14 of human Histone H2B. Clone MC603. 克隆 MC603 宿主 Rabbit 特异性 phospho-histone H2B (Ser14) 同种型 IgG 品种反应性 Human Species Reactivity Note Broad species cross-reactivity expected based on sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_175055.2
Entrez基因汇总 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. 基因符号 - HIST3H2BB
修改 - Phosphorylation
纯化方法 Protein A purfied UniProt编号 - Q8N257
UniProt汇总 FUNCTION: SwissProt: Q8N257 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
SIZE: 126 amino acids; 13908 Da
SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
SUBCELLULAR LOCATION: Nucleus.
PTM: Monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. & Phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class- switch recombination.
SIMILARITY: SwissProt: Q8N257 ## Belongs to the histone H2B family.产品使用声明 质量保证 Routinely evaluated by flow cytometry. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at 4°C from date of shipment 包装信息 数量 50 µg
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