- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Rb, Ch, H, M, R IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-386 品牌系列 Upstate
商名 - Upstate
描述 Anti-Vinculin Antibody, clone V284 产品信息 格式 Purified 演示 PBS, pH 7.4, containing 0.05% sodium azide and 1mg/ml BSA 应用 应用 Anti-Vinculin Antibody, clone V284 detects level of Vinculin & has been published & validated for use in IP, WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 Human Vinculin 克隆 clone V284 宿主 Mouse 特异性 Vinculin 同种型 IgG1 品种反应性 RabbitChickenHumanMouseRat 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_003373
Entrez基因汇总 Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Human vinculin protein exhibits a greater than 95% sequence identity to the chicken vinculin protein. 基因符号 - Vinculin
- VCL
- Metavinculin
- OTTHUMP00000043885
- vinculin
- MVCL
纯化方法 Protein A chromatography UniProt编号 - P18206
UniProt汇总 FUNCTION: SwissProt: P18206 # Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. May also play important roles in cell morphology and locomotion.
SIZE: 1134 amino acids; 123799 Da
SUBUNIT: Exhibits self-association properties. Interacts with NRAP and SORBS1 (By similarity). Interacts with TLN1.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell junction, adherens junction; Cytoplasmic side. Note=Cytoplasmic face of adhesion plaques.
TISSUE SPECIFICITY: Metavinculin is muscle-specific.
PTM: Phosphorylated on serines, threonines and tyrosines and acylated by myristic acid and/or palmitic acid.
DISEASE:SwissProt: P18206 # Defects in VCL are a cause of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM).
SIMILARITY: SwissProt: P18206 ## Belongs to the vinculin/alpha-catenin family.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates of human A431 cells, lysates from chicken embryonic fibroblasts (CEF), or mouse 3T3/A31 fibroblasts 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,MAB5270-50UG,Anti-Choline Acetyltransferase Antibody, clone 1.B3.9B3
下一件merck millipore产品：merck millipore,默克密理博,444905,Anti-Mast Cell Tryptase Mouse mAb (AA1)
相关产品
merck millipore,默克密理博,UFC805008,Amicon Ultra-4，PLQK Ultracel-PL 超滤膜，50 kDa
merck millipore,默克密理博,AP124-K,Goat anti-Mouse IgG (H&L) Affinity Purified (1mg)
merck millipore,默克密理博,06-225,Anti-c-Jun Antibody
merck millipore,默克密理博,MAB5270-50UG,Anti-Choline Acetyltransferase Antibody, clone 1.B3.9B3
merck millipore,默克密理博,444905,Anti-Mast Cell Tryptase Mouse mAb (AA1)
merck millipore,默克密理博,14-723,CaM Kinase IIδ Protein, active, 10 µg
merck millipore,默克密理博,ABF258,Anti-TSPYL2 Antibody
merck millipore,默克密理博,MABF733,Anti-KLRG1 Antibody (mouse), APC, clone 2F1
