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merck millipore,默克密理博,06-225,Anti-c-Jun Antibody
产品名称：Anti-c-Jun Antibody
产品型号：06-225
Detect c-Jun also known as JNK1 alpha protein kinase, JNK1 beta protein kinase with Anti-c-Jun Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in IP, WB, ICC.
merck millipore,默克密理博,06-225,Anti-c-Jun Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, Av, H ICC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 06-225 Replaces 04-210 品牌系列 Upstate
商名 - Upstate
描述 Anti-c-Jun Antibody 背景信息 c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements and appears to be a major downstream target of the SAPK/JNK signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced
signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun.产品信息 格式 Serum 控制 - Jurkat cell lysate
演示 whole rabbit antiserum containing 0.05% sodium azide 应用 应用 Detect c-Jun also known as JNK1 alpha protein kinase, JNK1 beta protein kinase with Anti-c-Jun Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in IP, WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 Trp E fusion-protein containing the DNA binding domain of avian c-Jun 宿主 Rabbit 特异性 c-Jun 同种型 IgG 品种反应性 MouseAvianHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_010591
Entrez基因汇总 This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. 基因符号 - c-Jun
- JUN
- p39
- AP1
纯化方法 Antiserum UniProt编号 - P05412
UniProt汇总 FUNCTION: SwissProt: P05412 # Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.
SIZE: 331 amino acids; 35676 Da
SUBUNIT: Interacts with FOS to form a dimer. Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.
SIMILARITY: SwissProt: P05412 ## Belongs to the bZIP family. Jun subfamily. & Contains 1 bZIP domain.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from human A431 cells or in Jurkat cell lysate 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µL
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