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  • merck millipore,默克密理博,14-912,TGFBR-1 Protein, active, 10 µg

  • merck millipore,默克密理博,14-912,TGFBR-1 Protein, active, 10 µg

    产品名称：TGFBR-1 Protein, active, 10 µg
    产品型号：14-912
    Active, N-terminal GST-tagged, recombinant, human TGFBR1 amino acids 200–end containing a T204D mutation, expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose. For use in  More>>

    merck millipore,默克密理博,14-912,TGFBR-1 Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-912,TGFBR-1 Protein, active, 10 µg

    描述
    产品目录编号 14-912
    品牌系列 Upstate
    商名
    • Upstate
    描述 TGFBR-1 Protein, active, 10 µg
    概述 N-terminal GST-tagged, recombinant, human TGFBR1 amino acids 200–end containing a T204D mutation, expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose.
    Alternate Names
    • ALK-5
    • TGF-beta receptor type-1
    • TGFR-1
    • Transforming growth factor-beta receptor type I
    • TGF-beta receptor type I
    • TbetaR-I
    • TGF-beta type I receptor
    • Activin receptor-like kinase 5
    • SKR4
    • Serine/threonine-protein kinase receptor R4
    背景信息 Transforming growth factor, beta receptor type I (TGF-beta receptor I) forms a heteromeric complex with TGF-beta receptor type II when bound to TGF-beta. This complex transduces the TGF-beta signal from the cell surface to the cytoplasm. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. TGF-beta receptor I is found in all tissues, but is most abundant in placenta and least abundant in brain and heart tissue. TGF-beta receptor I is phosphorylated at basal levels in the absence of ligand binding and is multiply phosphorylated, mainly in the GS region. Defects in TGF-beta receptor I are the cause of Loeys-Dietz syndrome type 1A (LDS1A), also known as Furlong syndrome or Loeys-Dietz aortic aneurysm syndrome (LDAS).
    产品信息
    演示 50mM Tris-HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
    应用
    应用 Active, N-terminal GST-tagged, recombinant, human TGFBR1 amino acids 200–end containing a T204D mutation, expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed by baculovirus in Sf21 insect cells.
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_004612
    基因符号
    • TGFBR1
    蛋白靶 TGFBR1
    纯化方法 Glutathione agarose affinity chromatography
    靶子系列 TKL
    UniProt编号
    • Q64729 (mouse)
    • P36897
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of casein.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store -70°C. For maximum recovery of product, centrifuge original vial prior to removing the cap.
    Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.
    包装信息
    数量 10 µg
    包装 Also available in 250 µg size --call for pricing and availability and reference catalog number 14-912M when ordering the 250 µg size.

    merck millipore,默克密理博,14-912,TGFBR-1 Protein, active, 10 µg

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