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描述 产品目录编号 14-865 品牌系列 Upstate
商名 - Upstate
描述 p53-GST (recombinant protein) 概述 N-terminal GST-tagged, recombinant full length human P53 protein, expressed in E. coli. Purified using glutathione agarose chromatography. Alternate Names - transformation related protein 53
产品信息 演示 Recombinant protein in buffer containing 20 mM Tris-HCl, pH 8.0, 100 mM KCl, 5mM glutathione, 0.5 mM EDTA, 0.5 mM DTT, 1 mM PMSF containing 20% glycerol. 应用 主要应用 - Enzyme Assay
生物信息 浓缩 0.5 mg/mL 纯度 ~95% by SDS-PAGE 来源 Full-length human p53 protein, expressed in e. coli. 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NP_000537
Entrez基因汇总 This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq] 基因符号 - LFS1
- p53
- TP53
- tumor protein p53
- TRP53
- FLJ92943
纯化方法 Glutathione agarose chromatography UniProt编号 - P04637
产品使用声明 质量保证 Routinely evaluated by SDS-PAGE and Coomassie Stain 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -20°C 包装信息 数量 50 µg
上一件merck millipore产品：merck millipore,默克密理博,658551,AG 1296 - CAS 146535-11-7 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,69182,DNase I, RNase free
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