merck millipore,默克密理博,658551,AG 1296 - CAS 146535-11-7

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

merck millipore,默克密理博,658551,AG 1296 - CAS 146535-11-7 - Calbiochem

经验配方	CAS号
C₁₆H₁₄N₂O₂	146535-11-7

描述
概述	Similar to but more potent than AG 1295 (Cat. No. 658550). A cell-permeable, reversible, and ATP-competitive, inhibitor of PDGF receptor kinase and blocks signaling of human PDGF α-receptors (IC₅₀ = 1.0 µM) and β-receptors (IC₅₀ = 800 nM) as well as of the related stem cell factor receptor c-kit (80% inhibition at 5 µM). Affects neither the binding of PDGF-BB to the PDGF-β receptor nor the receptor dimerization. Has no effect on autophosphorylation of the vascular endothelial growth factor receptor KDR or on DNA synthesis induced by vascular endothelial growth factor in porcine aortic endothelial cells. Also reverses the transformed phenotype of sis-transfected NIH/3T3 cells but has no effect on src-transformed NIH 3T3 cells or on the activity of the kinase p60^c-src (F257) immunoprecipitated from these cells. Potently inhibits autophosphorylation in Flt3/Tel-BaF3 and Flt3/Itd-BaF3 cells with an IC₅₀ of 300 nM and ~1 µM, respectively.
产品目录编号	658551
品牌系列	Calbiochem®
同义词	6,7-Dimethoxy-3-phenylquinoxaline

参考
参考	Tse, KF., et al. 2002. Leukemia 16, 2027. Tse, KF., et al. 2001. Leukemia 15, 1001. Strutz, F., et al. 2001. Kidney Int. 59, 579. Kovalenko, M., et al. 1997. Biochemistry 36, 6260. Kovalenko, M., et al. 1994. Cancer Res. 54, 6106.

生物信息
主靶	PDGFR kinase
主靶IC₅₀	1.0 µM, 800 nM, against signaling of human PDGF α-receptors, human PDGF β-receptors, respectively
纯度	≥98% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or ACN

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

merck millipore,默克密理博,658551,AG 1296 - CAS 146535-11-7 - Calbiochem

whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech