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merck millipore,默克密理博,616382,Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem
产品名称：Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem
产品型号：616382
Inhibits trypsin-like serine proteinases.
merck millipore,默克密理博,616382,Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem
- 产品介绍
- merck millipore,默克密理博,616382,Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem
重要规格表
经验配方 CAS号 C₁₄H₂₁ClN₂O₃S . HCl 4238-41-9 描述 概述 Inhibits trypsin-like serine proteinases. Irreversibly inactivates trypsin without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to the target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC50 = 80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemia cells and normal thymocytes. 产品目录编号 616382 品牌系列 Calbiochem®
同义词 TLCK 参考 参考 Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
Kim, H., et al. 1995. J. Immunol. 154, 4741.
Bourinbaiar, A.S. and Nagorny, R. 1994. Cell Immunol. 155, 230.
Biro, A., et al. 1992. Eur. J. Immunol. 22, 2547.
Bruno, S., et al. 1992. Leukemia 6, 1113.
Lee, S.F. 1992. Infect. Immun. 60, 4032.
Schmidt, H.H., et al. 1992. Mol. Pharmacol. 41, 615.产品信息 CAS号 4238-41-9 具有ATP竞争性 N 形式 Off-white solid Hill配方 C₁₄H₂₁ClN₂O₃S . HCl 化学配方 C₁₄H₂₁ClN₂O₃S . HCl Molar Mass 369.3 吸湿 Hygroscopic
可逆 N 结构配方图像 生物信息 主靶 trypsin like proteases 主靶IC50 EC50 = 80 µM blocking nitric oxide synthase induced by interferon-γ and lipopolysaccharides in macrophages 纯度 ≥95% by elemental analysis 理化信息 细胞可渗透 N 溶解度 aqueous solutions (unstable above pH 6.0) GHS安全信息 RTECS XT5160000 安全信息 R相 R: 36/37/38
Irritating to eyes, respiratory system and skin.S相 S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 +2°C to +8°C
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Unstable in solution; reconstitute just prior to use.
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