merck millipore,默克密理愽
  • merck millipore,默克密理博,14-555,Alk Protein, active, 10 µg

  • merck millipore,默克密理博,14-555,Alk Protein, active, 10 µg

    产品名称：Alk Protein, active, 10 µg
    产品型号：14-555
    Active, N-terminal His6-tagged, recombinant human ALK, residues 1058-end, for use in Kinase Assays.

    merck millipore,默克密理博,14-555,Alk Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-555,Alk Protein, active, 10 µg

    描述
    产品目录编号 14-555
    品牌系列 Upstate
    商名
    • Upstate
    描述 Alk Protein, active, 10 µg
    概述 N-terminal His6-tagged, recombinant human ALK, residues 1058-end
    应用
    应用 Active, N-terminal His6-tagged, recombinant human ALK, residues 1058-end, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed by baculovirus in Sf21 cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_004304.3
    Entrez基因汇总 The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
    基因符号
    • TFG/ALK
    • ALK
    • CD246
    蛋白靶 ALK
    纯化方法 Ni2+/NTA-agarose
    靶子系列 TK
    UniProt编号
    • Q9UM73
    UniProt汇总 FUNCTION: SwissProt: Q9UM73 # Orphan receptor with a tyrosine-protein kinase activity. Appears to play an important role in the normal development and function of the nervous system. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif.
    SIZE: 1620 amino acids; 176428 Da
    SUBUNIT: Homodimer. When bound to ligand.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.
    PTM: N-glycosylated.
    DISEASE: SwissProt: Q9UM73 # A chromosomal aberration involving ALK is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with NPM1. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. The constitutively active fusion proteins are responsible for 5-10% of non-Hodgkin lymphomas. & A chromosomal aberration involving ALK is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with CARS; translocation t(2;4)(p23;q21) with SEC31A. & A chromosomal aberration involving ALK is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALO17.
    SIMILARITY: SwissProt: Q9UM73 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 1 LDL-receptor class A domain. & Contains 2 MAM domains. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of IGF-1Rtide
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C from date of shipment
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-555,Alk Protein, active, 10 µg

上一件merck millipore产品：merck millipore,默克密理博,250600,Cytochrome c, Equine Heart
下一件merck millipore产品：merck millipore,默克密理博,AB260-K,Rabbit Anti-Sheep IgG


相关产品

merck millipore,默克密理博,SF-2054,FANCD2; Human, Cyanine 5 RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-2054,FANCD2; Human, Cyanine 5 RNA Detection Probe,SmartFlare

merck millipore,默克密理博,07-688,Anti-DNMT1 Antibody merck millipore,默克密理博,07-688,Anti-DNMT1 Antibody

merck millipore,默克密理博,05-1946,Anti-USP7 Antibody, clone 1G7 merck millipore,默克密理博,05-1946,Anti-USP7 Antibody, clone 1G7

merck millipore,默克密理博,489475,Anti-LRP-5/6 Mouse mAb (1A12) merck millipore,默克密理博,489475,Anti-LRP-5/6 Mouse mAb (1A12)

merck millipore,默克密理博,250600,Cytochrome c, Equine Heart merck millipore,默克密理博,250600,Cytochrome c, Equine Heart

merck millipore,默克密理博,AB260-K,Rabbit Anti-Sheep IgG merck millipore,默克密理博,AB260-K,Rabbit Anti-Sheep IgG

merck millipore,默克密理博,07-1720,Anti-FOXO4 Antibody merck millipore,默克密理博,07-1720,Anti-FOXO4 Antibody

merck millipore,默克密理博,AB5250-200UL,Anti-Potassium Channel TASK1 Antibody merck millipore,默克密理博,AB5250-200UL,Anti-Potassium Channel TASK1 Antibody

merck millipore,默克密理博,MABE545,Anti-LSD1 Antibody, clone EPR6825, rabbit monoclonal merck millipore,默克密理博,MABE545,Anti-LSD1 Antibody, clone EPR6825, rabbit monoclonal

merck millipore,默克密理博,14-706,MEK1 (6His) Protein, unactive, 50 µg merck millipore,默克密理博,14-706,MEK1 (6His) Protein, unactive, 50 µg


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部