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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-688 品牌系列 Upstate
商名 - Upstate
描述 Anti-DNMT1 Antibody 产品信息 格式 Serum 应用 应用 Detect DNMT1 also known as DNA (cytosine-5)-methyltransferase 1 with Anti-DNMT1 Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 fusion protein corresponding to residues 913-1085 of human DNA methyltransferase 1 (DNMT1) 宿主 Rabbit 特异性 DNMT1 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001379.1
Entrez基因汇总 DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. 基因符号 - MGC104992
- DNMT1
- Dnmt1
- M.HsaI
- DNA
- FLJ16293
- MCMT
- AIM
- DNMT
- CXXC9
纯化方法 Serum UniProt编号 - P26358
UniProt汇总 FUNCTION: SwissProt: P26358 # Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2.
SIZE: 1616 amino acids; 183165 Da
SUBUNIT: Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Component of complexes containing SUV39H1.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.
SIMILARITY: SwissProt: P26358 ## Belongs to the C5-methyltransferase family. & Contains 2 BAH domains. & Contains 1 CXXC-type zinc finger.产品使用声明 质量保证 Routinely evaluated by immunoblot with RIPA lysates from HeLa nuclear extracts. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 100 µL
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