merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5250-200UL,Anti-Potassium Channel TASK1 Antibody

  • merck millipore,默克密理博,AB5250-200UL,Anti-Potassium Channel TASK1 Antibody

    产品名称：Anti-Potassium Channel TASK1 Antibody
    产品型号：AB5250-200UL
    Anti-Potassium Channel TASK1 Antibody detects level of Potassium Channel TASK1 & has been published & validated for use in IH & WB.

    merck millipore,默克密理博,AB5250-200UL,Anti-Potassium Channel TASK1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5250-200UL,Anti-Potassium Channel TASK1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HWB, IHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5250-200UL
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Potassium Channel TASK1 Antibody
    Alternate Names
    • Kcnk3
    • TWIK-Related Acid Sensitive
    • TASK-1
    • cTBAK
    产品信息
    格式 Affinity Purified
    控制
    • CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of purified peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
    演示 Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, 5% sucrose as a stabilizer and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
    应用
    应用 Anti-Potassium Channel TASK1 Antibody detects level of Potassium Channel TASK1 & has been published & validated for use in IH & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Western blot: 1:200 using ECL on rat brain membranes.

    Immunohistochemistry on rat brain sections.

    Dilutions should be made using a carrier protein such as BSA (1-3%)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 A purified peptide (TASK) corresponding to amino acid residues 252-269 in the cytoplasmic C-terminus of human TASK1 (Accession O14649).
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 The epitope is specific for TASK1 and is not present in any other known proteins tested so far.

    SPECIES REACTIVITIES: The epitope is also highly conserved between mouse and rat (17/18 residues identical) but other species have not been tested.
    品种反应性 RatHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002246
    Entrez基因汇总 This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq]
    基因符号
    • TBAK1
    • KCNK3
    • KT3.1
    • K2p3.1
    • TASK-1
    • TASK1
    • OAT1
    UniProt编号
    • O14649
    UniProt汇总 FUNCTION: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.
    SIZE: 43518 Da [This is the MW of the unprocessed precursor].
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
    TISSUE SPECIFICITY: Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.
    MISCELLANEOUS: Inhibited by external acidification. Activated by halothane and isoflurane.
    SIMILARITY: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,AB5250-200UL,Anti-Potassium Channel TASK1 Antibody

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