merck millipore,默克密理愽
  • merck millipore,默克密理博,385920,HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem

  • merck millipore,默克密理博,385920,HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem

    产品名称：HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem
    产品型号：385920
    The HSP90 Inhibitor, CCT018159, also referenced under CAS 171009-07-7, controls the biological activity of HSP90.

    merck millipore,默克密理博,385920,HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,385920,HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₂₀N₂O₄171009-07-7
    描述
    概述 A cell-permeable pyrazoloresorcinol compound that inhibits HSP90 ATPase activity (IC50 = 3.2 µM and 6.6 µM against human HSP90β and yeast HSP90, respectively) by targeting the enzyme's N-terminal ATP binding site. It exhibits no detectable effects against human Hsp70 or topoisomerase II even at concentrations as high as 100 µM and inhibits a panel of 20 commonly studied kinases only at much higher concentrations. Unlike 17-AAG (Cat. No. 100068), the antitumor activity of CCT018159 is not affected by the expression of NQ01/DT-diaphorase or P-glycoprotein.
    产品目录编号 385920
    品牌系列 Calbiochem®
    同义词 4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol
    参考
    参考 Hardcastle, A., et al. 2007. Mol. Cancer Ther. 6, 1112.
    Sharp, S.Y., et al. 2007. Cancer Res. 67, 2206.
    Smith, N.F., et al. 2006. Mol. Cancer Ther. 5, 1628.
    Dymock, B.W., et al. 2005. J. Med. Chem. 48, 4212.
    Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3338.
    产品信息
    CAS号 171009-07-7
    形式 White solid
    Hill配方 C₂₀H₂₀N₂O₄
    化学配方 C₂₀H₂₀N₂O₄
    Molar Mass 352.4
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO, EtOH, or H₂O
    安全信息
    R相 R: 36/37/38

    Irritating to eyes, respiratory system and skin.
    S相 S: 24/25-36/37/39

    Avoid contact with skin and eyes.
    Wear suitable protective clothing, gloves and eye/face protection.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solution are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,385920,HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem

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