merck millipore,默克密理博,MABS740,Anti-phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221), clone EPR5693, Rabbit Monoclonal Antibody

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merck millipore,默克密理博,MABS740,Anti-phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221), clone EPR5693, Rabbit Monoclonal Antibody
产品名称：Anti-phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221), clone EPR5693, Rabbit Monoclonal Antibody
产品型号：MABS740
This Anti-phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221), clone EPR5693, Rabbit Monoclonal Antibody is validated for use in Western Blotting and Immunohistochemistry and Flow Cytometry for the detectio More>>

merck millipore,默克密理博,MABS740,Anti-phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221), clone EPR5693, Rabbit Monoclonal Antibody

产品介绍

merck millipore,默克密理博,MABS740,Anti-phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221), clone EPR5693, Rabbit Monoclonal Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, H	FC, WB, IHC	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABS740
描述	Anti-phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221), clone EPR5693, Rabbit Monoclonal Antibody
Alternate Names	MAPK 10 Mitogen-activated protein kinase 10 MAP kinase 10
背景信息	Mitogen-activated protein kinase 10 (MAP kinase 10 or MAPK 10), also known as MAP kinase p49 3F12 or Stress-activated protein kinase 1b (SAPK1b) or Stress-activated protein kinase JNK3 or c-Jun N-terminal kinase 3, and encoded by the gene names MAPK10 or JNK3 or JNK3A or PRKM10, is distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group consists of three isoforms (JNK1, 2, and 3) and regulates transcription activity of the AP-1 complex, and release and regulation of cytochome c. JNK becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase MKK4 and MKK7. Unlike other JNK isoforms, JNK3 is only expressed in the heart and nervous system. JNK3 has been implicated in stress-induced neuronal apoptosis.

产品信息
格式	Unpurified
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	This Anti-phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221), clone EPR5693, Rabbit Monoclonal Antibody is validated for use in Western Blotting and Immunohistochemistry and Flow Cytometry for the detection of phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221).
主要应用	Flow Cytometry Western Blotting Immunohistochemistry
应用说明	Immunohistochemistry Analysis: A 1:100-250 dilution from a representative lot detected phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221) in human brain tissue. Flow Cytometry Analysis: A 1:100 dilution from a representative lot detected phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221) in HeLa cells. Produced in collaboration with Epitomics™

生物信息
免疫原品种	Synthetic peptide corresponding to human phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221).
克隆	EPR5693
浓缩	Please refer to lot specific datasheet.
宿主	Rabbit
同种型	IgG
品种反应性	MouseHuman
Species Reactivity Note	Human, Mouse
抗体类型	Monoclonal Antibody
基因符号	SAPK1B MAPK10 JNK3 JNK3A PRKM10
纯化方法	Unpurified
UniProt编号	P53779

产品使用声明
质量保证	Evaluated by Western Blotting in NIH/3T3 untreated and NIH/3T3 treated with Anisomycin cell lysates. Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221) in NIH/3T3 untreated and NIH/3T3 treated with Anisomycin cell lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.