merck millipore,默克密理愽
  • merck millipore,默克密理博,14-504,PKCδ Protein, active, 10 µg

  • merck millipore,默克密理博,14-504,PKCδ Protein, active, 10 µg

    产品名称：PKCδ Protein, active, 10 µg
    产品型号：14-504
    Active, N-terminal His6-tagged, recombinant amino acids 2-end, of human PKCδ. For use in Kinase Assays.

    merck millipore,默克密理博,14-504,PKCδ Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-504,PKCδ Protein, active, 10 µg

    描述
    产品目录编号 14-504
    品牌系列 Upstate
    商名
    • Upstate
    描述 PKCδ Protein, active, 10 µg
    概述 N-terminal His6-tagged, recombinant amino acids 2-end, of human PKCδ

    PKC Lipid activator (Catalog # 20-133) is required for use.
    应用
    应用 Active, N-terminal His6-tagged, recombinant amino acids 2-end, of human PKCδ. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Human PKCδ expressed in Sf21 cells.
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_212539.1
    • NM_006254.3
    Entrez基因汇总 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.
    基因符号
    • nPKC-delta
    • PRKCD
    • MGC49908
    • MAY1
    蛋白靶 PKCδ
    纯化方法 Ni2+/NTA-agarose
    靶子系列 AGC
    UniProt编号
    • Q05655
    UniProt汇总 FUNCTION: SwissProt: Q05655 # This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function.
    SIZE: 676 amino acids; 77477 Da
    SUBUNIT: Interacts with PDK1 (By similarity). Interacts with RAD9A and CDCP1.
    SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
    DOMAIN: SwissProt: Q05655 The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor. & The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a sequence-specific manner.
    PTM: Phosphorylated on Thr-507, within the activation loop. Autophosphorylated and/or phosphorylated. Although the Thr-507 phosphorylation occurs it is not a prerequisite for enzymatic activity (By similarity).
    SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of PKC Substrate Peptide
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg
    包装 Also available in 250 µg size --call for pricing and availability and reference catalog number 14-504M when ordering the 250 µg size.

    merck millipore,默克密理博,14-504,PKCδ Protein, active, 10 µg

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