merck millipore,默克密理博,688000,Y-27632 - CAS 146986-50-7

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merck millipore,默克密理博,688000,Y-27632 - CAS 146986-50-7 - Calbiochem
产品名称：Y-27632 - CAS 146986-50-7 - Calbiochem
产品型号：688000
A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK).

merck millipore,默克密理博,688000,Y-27632 - CAS 146986-50-7 - Calbiochem

产品介绍

merck millipore,默克密理博,688000,Y-27632 - CAS 146986-50-7 - Calbiochem

重要规格表

经验配方	CAS号
C₁₄H₂₁N₃O · 2HCl · H₂O	146986-50-7

描述
概述	A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (K_i = 140 nM for p160^ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKC_ε than p160^ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca²⁺ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. Pretreatment with Y-27632 reduces the risk of lung injury in rat models of sepsis. A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688001) in H₂O and a 10 mM solution in DMSO (Cat. No. 688002) are also available.
产品目录编号	688000
品牌系列	Calbiochem®
同义词	ROCK Inhibitor, (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI

参考
参考	Cinel, I., et al. 2012. J. Thorac . Dis. 4, 30. Watanabe, K., et al. 2007. Nature Biotech. 25, 681. Chitaley, K., et al. 2001. Nat. Med. 7, 119. Davies, S.P., et al. 2000. Biochem. J. 351, 95. Narumiya, S., et al. 2000. Methods Enzymol. 325, 273. Hirose, M., et al. 1998. J. Cell Biol. 141, 1625. Maekawa, M., et al. 1999. Science 285, 895. Uehata, M., et al. 1997. Nature 389, 990.

参考

Cinel, I., et al. 2012. J. Thorac . Dis. 4, 30.
Watanabe, K., et al. 2007. Nature Biotech. 25, 681.
Chitaley, K., et al. 2001. Nat. Med. 7, 119.
Davies, S.P., et al. 2000. Biochem. J. 351, 95.
Narumiya, S., et al. 2000. Methods Enzymol. 325, 273.
Hirose, M., et al. 1998. J. Cell Biol. 141, 1625.
Maekawa, M., et al. 1999. Science 285, 895.
Uehata, M., et al. 1997. Nature 389, 990.

产品信息
CAS号	146986-50-7
具有ATP竞争性	Y
声明	Sold under license of PCT Application W098/06,433A1 and under license from Mitsubishi Pharma Tanabe Corporation.
形式	White solid
Hill配方	C₁₄H₂₁N₃O · 2HCl · H₂O
化学配方	C₁₄H₂₁N₃O · 2HCl · H₂O
Molar Mass	338.3
吸湿	Hygroscopic
可逆	Y
结构配方图像

生物信息
主靶	p160 Rho-associated protein kinases (ROCK)
主靶K_i	140 nM for p160 Rho-associated protein kinases (ROCK)
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	H₂O

安全信息
R相	R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
S相	S: 36 Wear suitable protective clothing.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Harmful
储存	-20°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.