merck millipore,默克密理愽
  • merck millipore,默克密理博,310500,D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem

  • merck millipore,默克密理博,310500,D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem

    产品名称：D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem
    产品型号：310500
    A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC₅₀ = 12 µM) and stimulates Src kinase activity.

    merck millipore,默克密理博,310500,D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,310500,D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₄₁NO₂119567-63-4
    描述
    概述 A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 µM) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.
    产品目录编号 310500
    品牌系列 Calbiochem®
    同义词 DMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III
    参考
    参考 Cuvillier, O., et al. 1996. Nature 381, 800.
    Ohta, H., et al. 1995. Cancer Res. 55, 691.
    Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585.
    Hanada, K., et al. 1991. Biochemistry 30, 11682.
    Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.
    产品信息
    CAS号 119567-63-4
    具有ATP竞争性 N
    形式 Waxy solid/Clear oil
    Hill配方 C₂₀H₄₁NO₂
    化学配方 C₂₀H₄₁NO₂
    Molar Mass 327.6
    可逆 Y
    结构配方图像
    生物信息
    主靶 PKC
    主靶IC50 12 µM against PKC
    纯度 ≥98% by TLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO, MeOH, or EtOH
    安全信息
    R相 R: 36/37/38

    Irritating to eyes, respiratory system and skin.
    S相 S: 26-36

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

    merck millipore,默克密理博,310500,D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem

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