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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-691 品牌系列 Upstate
商名 - Upstate
描述 Anti-MEKK3 Antibody 产品信息 格式 Affinity Purified 应用 应用 Anti-MEKK3 Antibody detects level of MEKK3 & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 synthetic peptide corresponding to amino acids 254-268 of human mitogen-activated protein kinase kinase kinase 3 (MEKK3) 宿主 Rabbit 特异性 MEKK3 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_203351.1
- NM_002401.3
Entrez基因汇总 This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. 基因符号 - MEKK3
- MAP3K3
- MAPKKK3
纯化方法 Immunoaffinity purified UniProt编号 - Q99759
UniProt汇总 FUNCTION: SwissProt: Q99759 # Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.
COFACTOR: Magnesium.
SIZE: 626 amino acids; 70898 Da
SUBUNIT: Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a complex with MAP2K3, RAC1 and CCM2. Interacts with MAP2K5 and SPAG9.
SIMILARITY: SwissProt: Q99759 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. & Contains 1 OPR domain. & Contains 1 protein kinase domain.产品使用声明 质量保证 Routinely evaluated by immunoblot with RIPA lysates from 3T3/A31 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -20°C from date of shipment 包装信息 数量 100 µL
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