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描述 产品目录编号 13-124 品牌系列 Upstate
商名 - Upstate
描述 IRS1 概述 N-terminal 6His-tagged, recombinant rat IRS1, expressed in Sf9 cells. Alternate Names - pp185
- Insulin Receptor Substrate 1
产品信息 演示 50mM Tris-HCl, 150mM NaCl, 250mM Imidazole, pH7.5, and 10% glycerol 应用 主要应用 - Western Blotting
生物信息 纯度 Purity >50%, determined by SDS-PAGE and Coomassie blue staining. 来源 Rat IRS1 expressed in Sf9 cells. 品种 Rat Entrez基因编号 - NM_005544
基因符号 - HIRS-1
- IRS1
- IRS-1
物理形式 Frozen liquid UniProt编号 - P35568
UniProt汇总 FUNCTION: SwissProt: P35568 # May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
SIZE: 1242 amino acids; 131591 Da
SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit via the phosphorylated YXXM motifs. Binds ROCK1. Binds to UBTF and PIK3CA in nuclear extracts (By similarity). Interacts with SOCS7.
PTM: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). & Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity).DISEASE:SwissProt: P35568 # Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
SIMILARITY: SwissProt: P35568 ## Contains 1 IRS-type PTB domain. & Contains 1 PH domain.产品使用声明 质量保证 Routinely evaluated by detecting IRS1 with anti-IRS1 (Cat. No. 06-248 or 06-526) 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable at -70°C for up to 1 year from date of receipt. 包装信息 数量 20 µg
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