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描述 概述 Recombinant, human TRAIL expressed in NSO cells a type II transmembrane protein with a C-terminal extracellular domain, which exhibits homology to other TNF family members. Displays potent antitumor activity against selected targets. Induces apoptosis in a number of transformed cell lines but not in normal tissues. 产品目录编号 616376 品牌系列 Calbiochem®
同义词 Apo2L; TNF-Related Apoptosis-Inducing Ligand 参考 参考 Griffith, T.S., et al. 1999. J. Exp. Med. 189, 1343.
Mariani, S.M., et al. 1997. J. Cell Biol. 137, 221.
Pan, G., et al. 1997. Science 277, 815.
Pan, G., et al. 1997. Science 276, 111.
Sheridan, J.P., et al. 1997. Science 277, 818.
Pitti, R.M., et al. 1996. J. Biol. Chem. 271, 12687.产品信息 形式 Lyophilized 配方 Lyophilized from sterile-filtered PBS, 50 µg BSA/µg TRAIL, pH 7.4. Molar Mass 21000 生物信息 生物活性 ED₅₀ = 4-12 ng/ml as measured by its ability to induce cytotoxicity in mouse L-929 cell line in the presence of metabolic inhibitors actinomycin D 纯度 ≥97% by SDS-PAGE 理化信息 污染物 Endotoxin: ≤1 EU/µg TRAIL 溶解度 Sterile PBS containing ≥0.1% BSA 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 ≤ -70°C
无需冷冻 No
特殊指南 Following reconstitution, refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C or -70°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or up to 3 months at -20°C or -70°C. Avoid freeze/thaw cycles of solutions. 加拿大出口规定 Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
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