merck millipore,默克密理博,129876,Amiloride, Hydrochloride - CAS 2016-88-8

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merck millipore,默克密理博,129876,Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem
产品名称：Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem
产品型号：129876
An inhibitor of angiogenesis.

merck millipore,默克密理博,129876,Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem

产品介绍

merck millipore,默克密理博,129876,Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem

重要规格表

经验配方	CAS号
C₆H₈ClN₇O • HCl	2016-88-8

描述
概述	An inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na⁺ entry and Na⁺,K⁺-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na⁺/H⁺ exchange pathway.
产品目录编号	129876
品牌系列	Calbiochem®
同义词	Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I

参考
参考	Knoll, A., et al. 1999. Microvasc. Res. 58, 1. Swiercz, R., et al. 1999. Oncol. Rep. 6, 523. Moran, A., et al. 1995. Am. J. Physiol. 268, C350. Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245. Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215. Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101. Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.

参考

Knoll, A., et al. 1999. Microvasc. Res. 58, 1.
Swiercz, R., et al. 1999. Oncol. Rep. 6, 523.
Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215.
Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101.
Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.

产品信息
CAS号	2016-88-8
具有ATP竞争性	N
形式	Off-white to yellow solid
Hill配方	C₆H₈ClN₇O • HCl
化学配方	C₆H₈ClN₇O • HCl
吸湿	Hygroscopic
可逆	Y
结构配方图像

生物信息
主靶	capillary morphogenesis
主靶IC₅₀	130 µM inhibiting capillary morphogenesis completely and reversibly
纯度	≥98% by HPLC

理化信息
细胞可渗透	N
溶解度	DMSO or H₂O

GHS安全信息
RTECS	UQ2275500

安全信息
R相	R: 25 Toxic if swallowed.
S相	S: 45-36 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Wear suitable protective clothing.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Toxic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	+15°C to +30°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.