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merck millipore,默克密理博,06-1304,Anti-SETD8 (hPR-SET7) Antibody
产品名称：Anti-SETD8 (hPR-SET7) Antibody
产品型号：06-1304
Anti-SETD8 (hPR-SET7) Antibody is a Rabbit Polyclonal Antibody for detection of SETD8 (hPR-SET7) also known as Histone-lysine N-methyltransferase SETD8 & has been validated in WB.
merck millipore,默克密理博,06-1304,Anti-SETD8 (hPR-SET7) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 06-1304 Replaces 07-316 描述 Anti-SETD8 (hPR-SET7) Antibody Alternate Names - Histone-lysine N-methyltransferase SETD8
背景信息 SETD8 (hPR-SET7) is a histone methyltransferase that adds a single methyl group to 'Lys-20' of histone H4. H4 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. SETD8 (hPR-SET7) is located in the nucleus and may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail. 产品信息 格式 Affinity Purified 控制 - HeLa nuclear extract.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.150 mM NaCl and 0.05% sodium azide. 应用 应用 Anti-SETD8 (hPR-SET7) Antibody is a Rabbit Polyclonal Antibody for detection of SETD8 (hPR-SET7) also known as Histone-lysine N-methyltransferase SETD8 & has been validated in WB. 主要应用 - Western Blotting
应用说明 Immunocytochemistry: This antibody has been reported by an independent laboratory to detect SETD8 (hPR-SET7) in HeLa cells. 生物信息 免疫原品种 GST-tagged recombinant protein corresponding to human SETD8 (hPR-SET7). 宿主 Rabbit 特异性 This antibody recognizes SETD8 (hPR-SET7). 品种反应性 RatHumanMouse Species Reactivity Note Proven to react with human. Predicted to react with mouse and rat based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_065115.3
基因符号 - hPR-SET7
- SETD8
- PR-SET7
纯化方法 Affinity Purfied UniProt编号 - Q9NQR1
UniProt汇总 Function: Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones.
Catalytic activity: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
Subcellular location: Nucleus. Note: Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin.
Developmental stage: Not detected during G1 phase. First detected during S through G2 phases, and peaks during mitosis (at protein level).
Induction: By HCFC1 C-terminal chain, independently of HCFC1 N-terminal chain.
Domain: Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.
Sequence similarities: Belongs to the histone-lysine methyltransferase family. PR/SET subfamily. Contains 1 SET domain.产品使用声明 质量保证 Evaluated by Western Blot in HeLa nuclear extract.
Western Blot Analysis: 1:1,000 dilution of this antibody detected SETD8 (hPR-SET7) on 10 µg of HeLa nuclear extract.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable at 2-8°C for 1 year from date of receipt. 包装信息 数量 100 µL
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