merck millipore,默克密理博,110145,D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6

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merck millipore,默克密理博,110145,D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem
产品名称：D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem
产品型号：110145
Biologically active, cell-permeable, non-physiological ceramide analog.

merck millipore,默克密理博,110145,D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem

产品介绍

merck millipore,默克密理博,110145,D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem

重要规格表

经验配方	CAS号
C₂₀H₃₉NO₃	3102-57-6

描述
概述	Biologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis in HL-60 cells. Induces intranucleosomal DNA fragmentation. An activator of heterotrimeric protein phosphatase 2A (PP2A). Stimulates a cytosolic serine/threonine protein phosphatase in T9 cells at concentrations as low as 100 nM. Activates stress activated protein kinase (SAPK) in HL-60 human promyelocytic cells.
产品目录编号	110145
品牌系列	Calbiochem®
同义词	C₂ Ceramide

参考
参考	Westwick, J.K., et al. 1995. J. Biol. Chem. 270, 22689. Cifone, M.G., et al. 1994. J. Exp. Med. 180, 1547. Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125. Bielawska, A., et al. 1993. J. Biol. Chem. 268, 26226. Obeid, L.M., et al. 1993. Science 259, 1769. Ballou, L.R., et al. 1992. J. Biol. Chem. 267, 20044. Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.

参考

Westwick, J.K., et al. 1995. J. Biol. Chem. 270, 22689.
Cifone, M.G., et al. 1994. J. Exp. Med. 180, 1547.
Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
Bielawska, A., et al. 1993. J. Biol. Chem. 268, 26226.
Obeid, L.M., et al. 1993. Science 259, 1769.
Ballou, L.R., et al. 1992. J. Biol. Chem. 267, 20044.
Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.

产品信息
CAS号	3102-57-6
具有ATP竞争性	N
形式	White to off-white solid
Hill配方	C₂₀H₃₉NO₃
化学配方	C₂₀H₃₉NO₃
Molar Mass	341.5
可逆	N
结构配方图像

生物信息
主靶	Inhibits cell growth and induces apoptosis in HL-60 cells
纯度	≥98% by TLC

理化信息
细胞可渗透	Y
溶解度	DMSO or EtOH

安全信息
R相	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S相	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Irritant
储存	-20°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Alcohol stock solutions are stable for <1 week at -20°C.