merck millipore,默克密理愽
  • merck millipore,默克密理博,292505,Diethylamine NONOate/AM - CAS 213768-16-2 - Calbiochem

  • merck millipore,默克密理博,292505,Diethylamine NONOate/AM - CAS 213768-16-2 - Calbiochem

    产品名称：Diethylamine NONOate/AM - CAS 213768-16-2 - Calbiochem
    产品型号：292505
    An esterase-sensitive and cell permeable, O²-acetoxymethylated diazeniumdiolate that acts as an intracellular nitric oxide (NO) donor (1.83 mol of NO/mol).

    merck millipore,默克密理博,292505,Diethylamine NONOate/AM - CAS 213768-16-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,292505,Diethylamine NONOate/AM - CAS 213768-16-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₇H₁₅N₃O₄213768-16-2
    描述
    概述 An esterase-sensitive and cell permeable, O2-acetoxymethylated diazeniumdiolate that acts as an intracellular nitric oxide (NO) donor (1.83 mol of NO/mol). Shown to induce apoptosis and to act as an antiproliferative agent in NO-sensitive human leukemia HL-60 (IC50 = 8.3 µM) and U937 (IC50 = 53 µM) cell lines. Also suppresses oxidized low-density lipoprotein-induced caspase-3 activation in bovine aortic endothelial cells. Exhibits enhanced stability in physiological buffers. May also be useful for temporal and spatial controlled NO availability.
    产品目录编号 292505
    品牌系列 Calbiochem®
    参考
    参考 Kotamraju, S., et al. 2001. J. Biol. Chem. 276, 17316.
    Saavedra, J.E., et al. 2000. J. Med. Chem. 43, 261.
    产品信息
    CAS号 213768-16-2
    具有ATP竞争性 N
    形式 Yellow liquid
    Hill配方 C₇H₁₅N₃O₄
    化学配方 C₇H₁₅N₃O₄
    Molar Mass 205.2
    可逆 N
    结构配方图像
    生物信息
    主靶 Intracellular nitric oxide (NO) donor
    主靶IC50 8.3 µM, 53 µM, acting as an antiproliferative agent in NO-sensitive human leukemia HL-60 and U937 cell lines, respectively
    纯度 ≥95% by NMR
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    防潮 Protect from moisture
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 2 months at -20°C. Add to aqueous medium just prior to use.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,292505,Diethylamine NONOate/AM - CAS 213768-16-2 - Calbiochem

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