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merck millipore,默克密理博,ABN455,Anti-C9ORF72/C9RANT (poly-GP) Antibody
产品名称:Anti-C9ORF72/C9RANT (poly-GP) Antibody
产品型号:ABN455
Anti-C9ORF72/C9RANT (poly-GP), Cat # ABN455, is a highly validated rabbit Polyclonal antibody, that targets C9ORF72/C9RANT (poly-GP) and has been tested in Western Blotting and Immunohistochemistry.
merck millipore,默克密理博,ABN455,Anti-C9ORF72/C9RANT (poly-GP) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Unpurified Polyclonal Antibody 描述 产品目录编号 ABN455 描述 Anti-C9ORF72/C9RANT (poly-GP) Antibody Alternate Names - C9RANT
- C9ORF72
背景信息 In a noncoding region of C9ORF72 hexanucleotide (GGGGCC) repeat expansions are the major genetic cause of FTD and ALS (c9FTD/ALS). Transcripts that have the RNA structure of GGGGCC repeats are susceptible to an unconventional mechanism of translation called repeatassociated non-ATG (RAN) translation. Translation of the GGGGCC-repeat in all reading frames would result in three dipeptide-repeat (DPR) proteins poly-(Gly-Ala), poly-(Gly-Pro) and poly-(Gly-Arg). poly-GA and poly-GP proteins are extremely hydrophobic and may form intracellular aggregates. Anti-C9RANT, an antibody that was generated against putative GGGGCC repeat RANtranslated peptides mentioned above, detects insoluble high molecular weight material in brain homogenates, and neuronal inclusions throughout the CNS of c9FTD/ALS cases (Ash, PE, et al. (2013). Neuron. 77(4):639-46.) 产品信息 格式 Unpurified 演示 Rabbit Polyclonal serum with 0.05% sodium azide. 应用 应用 Anti-C9ORF72/C9RANT (poly-GP), Cat # ABN455, is a highly validated rabbit Polyclonal antibody, that targets C9ORF72/C9RANT (poly-GP) and has been tested in Western Blotting and Immunohistochemistry. 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:5000 dilution from a representative lot detected C9RANT (poly-GP) in human cerebellar sections of c9FTD cases (Ash, PE, et al. (2013). Neuron. 77(4):639-646.). 生物信息 免疫原品种 Linear peptides corresponding to C-Ahx-(GA)8-amide, C-Ahx-(GP)8-amide, and C-Ahx-
(GR)8-amide表位 poly-GP 浓缩 Please refer to lot specific datasheet. 宿主 Rabbit 品种反应性 Human Species Reactivity Note Human. Predicted to react with all species. 抗体类型 Polyclonal Antibody 纯化方法 Unpurified 产品使用声明 质量保证 Evaluated by Western Blotting in transfected HEK293 cell lysate.
Western Blotting Analysis: 1:2000 diultion of this antibody detected GST fusion protein with 5 GP repeats in 10 µg of transfected HEK293 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 50 µL
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