merck millipore,默克密理博,09-871,Anti-Elp1 Antibody

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merck millipore,默克密理博,09-871,Anti-Elp1 Antibody
产品名称：Anti-Elp1 Antibody
产品型号：09-871
Use Anti-Elp1 Antibody (Rabbit Polyclonal Antibody) validated in WB, IP to detect Elp1 also known as Elongator complex protein 1, ELP1, IkappaB kinase complex-associated protein.

merck millipore,默克密理博,09-871,Anti-Elp1 Antibody

产品介绍

merck millipore,默克密理博,09-871,Anti-Elp1 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Ca, M, H, R, Po, Rhesus Macaque, Eq, Chp	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	09-871
描述	Anti-Elp1 Antibody
Alternate Names	IKK complex-associated protein Elongator complex protein 1 ELP1 IkappaB kinase complex-associated protein
背景信息	Elongation protein 1 (Elp1), also referred to as IKAP (I-KappaB-Associated Protein) is a subunit of the RNA polymerase II elongator complex. As part of the RNA polymerase II (Pol II) holoenzyme, this protin functions as a histone acetyltransferase component involved in transcriptional elongation. Studies suggest that this protein plays a role in chromatin remodeling via acetylation of histones H3 and H4.

产品信息
格式	Affinity Purified
控制	Mouse embryonic stem cell lysate
演示	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Use Anti-Elp1 Antibody (Rabbit Polyclonal Antibody) validated in WB, IP to detect Elp1 also known as Elongator complex protein 1, ELP1, IkappaB kinase complex-associated protein.
主要应用	Western Blotting
应用说明	Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP. (Yi Zhang, Ph.D., Howard Hughes Medical Institute)

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to mouse Elp1.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
品种反应性	CanineMouseHumanRatPigRhesus MacaqueHorseChimpanzee
Species Reactivity Note	Demonstrated to react with Mouse. Predicted to react with Human, Rat, Porcine, Rhesus Macaque, Equine, Chimpanzee, and Canine based on 100% sequence homology.
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_080355
基因符号	Ikap Ikbkap Elp1
纯化方法	Affinity purified
UniProt编号	Q7TT37
UniProt汇总	FUNCTION: May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity). Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4 (By similarity). SUBUNIT STRUCTURE: Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). TISSUE SPECIFICTY: Widely expressed with highest levels in brain. DEVELOPMENTAL STAGE: Expressed at embryonic days 7, 11, 15 and 17 with the highest expression at embryonic day 11. PTM: Phosphorylated (By similarity). SEQUENCE SIMILARITIES: Belongs to the ELP1/IKA1 family. SEQUENCE CAUTION: The sequence AAL36025.1 differs from that shown. Reason: Frameshift at position 498. The sequence AAO15309.1 differs from that shown. Reason: Frameshift at several positions.

产品使用声明
质量保证	Evaluated by Western Blot in mouse embryonic stem cell lysate. Western Blot Analysis: 0.1 µg/mL of this antibody detected Elp1 on 10 µg of mouse embryonic stem cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,09-871,Anti-Elp1 Antibody

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