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merck millipore,默克密理博,217708,Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem
产品名称：Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem
产品型号：217708
The Cdc42/Rac1 GTPase Inhibitor, ML141 controls the biological activity of Cdc42/Rac1 GTPase. This small molecule/inhibitor is primarily used for Membrane applications.
merck millipore,默克密理博,217708,Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem
- 产品介绍
Replacement Information 重要规格表
经验配方 C₂₂H₂₁N₃O₃S 描述 概述 A cell-permeable, allosteric, trisubstituted dihydropyrazolyl compound that acts as a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPases (IC50 = 0.2, 2.6 and 5.4 µM against nucleotide depleted Cdc42-wt, Cdc42-wt and Cdc42 activated mutant, respectively) with excellent selectivity over Rho family GTPases (IC50 > 100 µM for Ras-wt, Ras activated mutant, Rab7-wt, Rab2a-wt, Rac1-wt and Rac1 activated mutant). Shown to efficiently block Cdc42 association with GTPγS and PAK-PBD, and decrease GTP-Cdc42 (> 95%) and GTP-Rac1 (≥40%) contents in EGF-stimulated 3T3 cells, and inhibit Bradykinin (Cat. No. 05-23-0500)-induced filopodia formation in 3T3 cells at 10 µM. 产品目录编号 217708 品牌系列 Calbiochem®
同义词 CID2950007, (±)-4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl))-benzenesulfonamide, (±)-4-(4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl)-benzenesulfonamide, MLS00693334, CDC42 GTPase Inhibitor II, CDC42 Inhibitor II, Rac1 Inhibitor V, Rac1 GTPase Inhibitor II 参考 参考 Hong, L., et al. 2012. J. Biol. Chem. in press.
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2010 Feb 27.产品信息 形式 Yellow-white solid Hill配方 C₂₂H₂₁N₃O₃S 化学配方 C₂₂H₂₁N₃O₃S Molar Mass 407.5 结构配方图像 应用 生物信息 纯度 ≥99% by HPLC 理化信息 溶解度 DMSO 尺寸 材料信息 毒性学信息 GHS安全信息 安全信息 产品使用声明 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
运输信息 补充信息 规格
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