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  • merck millipore,默克密理博,07-2112,Anti-FGFR-4 Antibody

  • merck millipore,默克密理博,07-2112,Anti-FGFR-4 Antibody

    产品名称：Anti-FGFR-4 Antibody
    产品型号：07-2112
    Anti-FGFR-4 Antibody is a highly specific rabbit polyclonal antibody, that targets FGFR4 & has been tested in western blotting.

    merck millipore,默克密理博,07-2112,Anti-FGFR-4 Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-2112,Anti-FGFR-4 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-2112
    描述 Anti-FGFR-4 Antibody
    Alternate Names
    • tyrosylprotein kinase
    • CD334 antigen
    • fibroblast growth factor receptor 4
    • hydroxyaryl-protein kinase
    • protein-tyrosine kinase
    • tyrosine kinase related to fibroblast growth factor<br />receptor
    背景信息 The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
    产品信息
    格式 Purified
    控制
    • Mouse lung tissue lysate
    演示 Purified rabbit serum in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-FGFR-4 Antibody is a highly specific rabbit polyclonal antibody, that targets FGFR4 & has been tested in western blotting.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH conjugated linear peptide selected from residues corresponding to human FGFR-4.
    表位 Unknown
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes FGFR-4.
    品种反应性 RatHumanMouse
    Species Reactivity Note Reacts with mouse and rat. 100% homology with human based on sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • Q03142
    基因符号
    • TKF
    • CD334
    • EC 2.7.10.1
    • FGFR-4
    • JTK2
    • MGC20292
    • OTTHUMP00000161430
    纯化方法 Affinity Purfied
    UniProt编号
    • P22455
    UniProt汇总 FUNCTION: Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.
    CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
    SUBUNIT STRUCTURE: Interacts with KLB By similarity.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Note: Isoform 2 may be secreted.
    TISSUE SPECIFICITY: Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.
    PTM: Glycosylated By similarity. Phosphorylated on tyrosine residue By similarity. Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization By similarity.
    SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in mouse lung tissue lysate.
    Western Blot Analysis: A 1:1000 dilution of this antibody detected FGFR4 on mouse lung tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C for up to 12 months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-2112,Anti-FGFR-4 Antibody

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