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merck millipore,默克密理博,09-295,Anti-phospho-Calmodulin (Tyr99) Antibody
产品名称：Anti-phospho-Calmodulin (Tyr99) Antibody
产品型号：09-295
Anti-phospho-Calmodulin (Tyr99) Antibody detects level of phospho-Calmodulin (Tyr99) & has been published & validated for use in WB.
merck millipore,默克密理博,09-295,Anti-phospho-Calmodulin (Tyr99) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M, B, Eq WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 09-295 描述 Anti-phospho-Calmodulin (Tyr99) Antibody Alternate Names - phosphorylase kinase, delta subunit
- calmodulin 1
- calmodulin 1 (phosphorylase kinase, delta)
背景信息 Calmodulin (CaM) is a ubiquitous, calcium-binding protein that can bind to and regulate a multitude of different protein targets, thereby affecting many different cellular functions.
CaM mediates processes such as inflammation, metabolism, apoptosis, muscle contraction, intracellular movement, short-term and long-term memory, nerve growth and the immune response. CaM is expressed in many cell types and can have different subcellular locations, including the cytoplasm, within organelles, or associated with the plasma or organelle membranes. Many of the proteins that CaM binds are unable to bind calcium themselves, and as such use CaM as a calcium sensor and signal transducer. CaM undergoes a conformational change upon binding to calcium, which enables it to bind to specific proteins for a specific response. CaM can bind up to four calcium ions, and can undergo post-translational modifications, such as phosphorylation, acetylation, methylation and proteolytic cleavage, each of which can potentially modulate its actions.产品信息 格式 Affinity Purified 控制 - EGF treated and untreated HeLa cell lysate
演示 Affinity purified rabbit serum in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-phospho-Calmodulin (Tyr99) Antibody detects level of phospho-Calmodulin (Tyr99) & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human phosphorylated Calmodulin at and around Tyr99. 表位 Phosphorylated Tyr99 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes phosphorylated Calmodulin at Tyr99. 品种反应性 RatHumanMouseBovineHorse Species Reactivity Note Reacts with human and mouse. Predicted to react with horse, rat and cow based on sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_008819.1
Entrez基因汇总 Calmodulin is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 149 amino acids and has 4 calcium-binding domains. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters. 基因符号 - CAM1
- CALM1
- CALML2
- CALM3
- CALM
- CaM
- CALM2
- CAM2
- CAMC
- CAM3
- DD132
- CAMIII
- PHKD
- CAMI
- CAMB
- CAM
修改 - Phosphorylation
纯化方法 Affinity Purfied UniProt编号 - P62158
UniProt汇总 FUNCTION: Calmodulin mediates the control of a large number of enzymes and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
SUBUNIT STRUCTURE: Interacts with MYO1C By similarity. Interacts with CEP97, CEP110, TTN/titin and SRY.
SUBCELLULAR LOCATION: Spindle. Note= Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
PTM: Ubiquitination results in a strongly decreased activity By similarity.
Phosphorylation results in a decreased activity By similarity.
MISCELLANEOUS: This protein has four functional calcium-binding sites.
SEQUENCE SIMILARITIES: Belongs to the calmodulin family.
Contains 4 EF-hand domains.
Sequence caution The sequence CAA36839.1 differs from that shown. Reason: Erroneous gene model prediction.产品使用声明 质量保证 Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Calmodulin phosphorylated at Tyr99 in EGF treated and untreated HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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