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  • merck millipore,默克密理博,ABE280,Anti-Ars2 Antibody

  • merck millipore,默克密理博,ABE280,Anti-Ars2 Antibody

    产品名称：Anti-Ars2 Antibody
    产品型号：ABE280
    Use Anti-Ars2 Antibody (Rabbit Polyclonal Antibody) validated in WB, IP to detect Ars2 also known as Serrate RNA effector molecule homolog, Arsenite-resistance protein 2.

    merck millipore,默克密理博,ABE280,Anti-Ars2 Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABE280,Anti-Ars2 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABE280
    描述 Anti-Ars2 Antibody
    Alternate Names
    • Arsenite-resistance protein 2
    • Serrate RNA effector molecule homolog
    背景信息 As a component of the nuclear RNA cap-binding complex (CBC), Ars2 is known to play a critical role in miRNA biogenesis by stabilizing and linking capped primary miRNA transcripts with the primary miRNA processing complex containing DROSHA and DGGR8. Unlike other CBC components, Ars2 expression also plays an important role in cell proliferation. In particular, depletion of Ars2 is shown to reduce the levels of several miRNAs, such as miR-21, let-7, and miR-155, which are implicated in cellular transformation.
    产品信息
    格式 Affinity Purified
    控制
    • HEK293 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-Ars2 Antibody (Rabbit Polyclonal Antibody) validated in WB, IP to detect Ars2 also known as Serrate RNA effector molecule homolog, Arsenite-resistance protein 2.
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation Analysis: A representative lot from an independent laboratory detected Ars2 in IP. (Alex Achille, Department of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA).
    生物信息
    免疫原品种 Linear peptide corresponding to human Ars2.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with Human, Rat, and Mouse.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001122324
    基因符号
    • ASR2
    • SRRT
    • ARS2
    纯化方法 Affinity purified
    UniProt编号
    • Q9BXP5
    UniProt汇总 FUNCTION: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.

    SUBUNIT STRUCTURE: Interacts with NCBP1 and DROSHA. Interacts with CASP8AP2 and ERBB4.

    TISSUE SPECIFICITY: Ubiquitously expressed.
    产品使用声明
    质量保证 Evaluated by Western Blot in HEK293 cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected Ars2 in 10 µg of HEK293 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABE280,Anti-Ars2 Antibody

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