merck millipore,默克密理博,FCMAB321F,Milli-Mark™ Anti-β-Tubulin-FITC Antibody, clone AA2

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
B, H, M, R	FC	M	FITC	Monoclonal Antibody

描述
产品目录编号	FCMAB321F
商名	Milli-Mark
描述	Milli-Mark™ Anti-β-Tubulin-FITC Antibody, clone AA2
Alternate Names	tubulin, beta polypeptide Tubulin beta-5 chain beta 5-tubulin beta Ib tubulin beta-4 tubulin tubulin beta polypeptide tubulin beta-1 chain tubulin, beta
背景信息	Microtubules are constituent parts of the mitotic apparatus, cilia, flagella, and elements of the cytoskeleton. They consist principally of 2 soluble proteins, alpha- and beta-tubulin, each about 55 kDa in size. Beta-tubulin binds to alpha tubulin to form tubulin heterodimer which is post-translationally modified . Beta tubulin influences the stability of the heterdimer, determined by whether the molecule of GTP bound to the beta tubulin subunit hydrolyzes to GDP along the microtubule protofilament. Beta tubulin has also been a target for various antitubulin agents used in the treatment of cancer. Studies have concluded that beta tubulin mutatons can contribute to drug resistance and may play a role in resistance to chemotherapy.

产品信息
格式	FITC
控制	A431 cells
演示	Purified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA

应用
应用	Milli-Mark Anti-β-Tubulin-FITC Antibody, clone AA2 detects level of β-Tubulin & has been published & validated for use in FC.
主要应用	Flow Cytometry

生物信息
免疫原品种	Purified bovine brain tubulin. The epitope recognized by this antibody has been mapped to amino acids 412-430.
克隆	AA2
宿主	Mouse
特异性	Antibody recognizes Human beta tubulin
同种型	IgG1
品种反应性	BovineHumanMouseRat
Species Reactivity Note	Tested and passed on Human. Predicted to react on bovine based on immunogen design.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_821133
基因符号	Tubb5 M40 MGC117247 MGC16435 OK/SW-cl.56 OTTHUMP00000029069 TUBB1 TUBB5
纯化方法	Protein G Purified
UniProt编号	P07437
UniProt汇总	FUNCTION: SwissProt: P07437 # Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. SIZE: 444 amino acids; 49671 Da SUBUNIT: Dimer of alpha and beta chains. TISSUE SPECIFICITY: Ubiquitously expressed with highest levels in spleen, thymus and immature brain. DOMAIN: SwissProt: P07437 The highly acidic C-terminal region may bind cations such as calcium.r />SIMILARITY: Belongs to the tubulin family.

产品使用声明
质量保证	Evaluated by flow cytometry using A431 cells
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB321F,Milli-Mark™ Anti-β-Tubulin-FITC Antibody, clone AA2

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