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品种反应性 主要应用 宿主 格式 抗体类型 R, H WB, ICC, IHC Rb Serum Polyclonal Antibody 描述 产品目录编号 AB15415 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-GABARAP Antibody Alternate Names - Gamma-aminobutyric acid receptor-associated protein, GABA(A) receptor-associated protein
- Gamma-aminobutyric acid receptor-associated protein
背景信息 Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. An important inhibitory neurotransmitter, GABA, acts on GABA receptors that are ubiquitously expressed in the CNS. GABARAP has been shown to play a important role in modulating the activities of GABA (A) receptors. 产品信息 格式 Serum 演示 Lyophilized. Reconstitute with 50 uL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative. 应用 应用 Anti-GABARAP Antibody detects level of GABARAP & has been published & validated for use in IC, IH & WB. 主要应用 - Western Blotting
- Immunocytochemistry
- Immunohistochemistry
应用说明 Western blot: 1:100-1:1,000
Immunocytochemistry: 1:100-1:1,000
Immunohistochemistry: 1:100-1:1,000
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide corresponding to a region within the N-terminus of human GABARAP protein. 宿主 Rabbit 特异性 GABARAP [Gamma-aminobutyric acid receptor-associated protein, GABA(A) receptor-associated protein]. 品种反应性 RatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_007278.1
Entrez基因汇总 Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. 基因符号 - FLJ25768
- GABARAP
- GABA
- MM46
- MGC120155
- MGC120154
纯化方法 Serum UniProt编号 - O95166
UniProt汇总 FUNCTION: SwissProt: O95166 # May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (By similarity).
SIZE: 117 amino acids; 13918 Da
SUBUNIT: Interacts with GPHN and NSF (By similarity). Interacts with GABRG2, beta-tubulin and ULK1.
SUBCELLULAR LOCATION: Intracytoplasmic membrane (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules (By similarity).
TISSUE SPECIFICITY: Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
SIMILARITY: SwissProt: O95166 ## Belongs to the MAP1 LC3 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability. 包装信息 数量 50 µL
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