merck millipore,默克密理博,07-865,Anti-phospho-PED/PEA-15 (Ser116) Antibody

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merck millipore,默克密理博,07-865,Anti-phospho-PED/PEA-15 (Ser116) Antibody
产品名称：Anti-phospho-PED/PEA-15 (Ser116) Antibody
产品型号：07-865
Anti-phospho-PED/PEA-15 (Ser116) Antibody detects level of phospho-PED/PEA-15 (Ser116) & has been published & validated for use in WB.

merck millipore,默克密理博,07-865,Anti-phospho-PED/PEA-15 (Ser116) Antibody

产品介绍

merck millipore,默克密理博,07-865,Anti-phospho-PED/PEA-15 (Ser116) Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-865
品牌系列	Upstate
商名	Upstate
描述	Anti-phospho-PED/PEA-15 (Ser116) Antibody
Alternate Names	PED (Phosphoprotein Enriched in Diabetes), PEA-15 (phosphoprotein enriched in astrocytes 15), RP11-536C5.8, HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15 PED (Phosphoprotein Enriched in Diabetes) PEA-15 (phosphoprotein enriched in astrocytes 15) RP11-536C5.8 HMAT1 HUMMAT1H MAT1 MAT1H

产品信息
格式	Affinity Purified
演示	100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg²⁺ and Ca²⁺), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.

应用
应用	Anti-phospho-PED/PEA-15 (Ser116) Antibody detects level of phospho-PED/PEA-15 (Ser116) & has been published & validated for use in WB.
主要应用	Western Blotting

生物信息
免疫原品种	Peptide corresponding to amino acid region encompassing the human, mouse, rat and frog phospho-PED/PEA-15 (Ser116).
宿主	Rabbit
特异性	Recognizes phospho-PED/PEA-15 (Ser116)
同种型	IgG
品种反应性	MouseHuman
Species Reactivity Note	Predicted to cross-react with rat based on sequence similarity, but has not been tested.
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_003768.2
Entrez基因汇总	PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.[supplied by OMIM]
基因符号	PEA-15 PEA15 PED MAT1 HMAT1 MAT1H HUMMAT1H
修改	Phosphorylation
纯化方法	Affinity Purfied
UniProt编号	Q15121
UniProt汇总	FUNCTION: SwissProt: Q15121 # Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. SIZE: 130 amino acids; 15040 Da SUBUNIT: Binds RPS6KA3, MAPK3 and MAPK1. Transient interaction with PLD1 and PLD2 (By similarity). Interacts with CASP8 and FADD. SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with microtubules. TISSUE SPECIFICITY: Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose- producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls. PTM: Phosphorylated by protein kinase C and calcium-calmodulin- dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones. SIMILARITY: SwissProt: Q15121 ## Contains 1 DED (death effector) domain.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 2 years at -20°C from date of shipment. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 2 years at -20°C from date of shipment.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.