- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE251 Replaces 06-892 描述 Anti-N-CoR Antibody Alternate Names - Retinoid X receptor-interacting protein 13
- Nuclear receptor corepressor 1
- N-CoR
- N-CoR1
背景信息 In the absence of ligands, the corepressor N-CoR represses nuclear hormone receptor-mediated gene transcription. In the presence of ligands, these hormone receptors activate gene expression and play critical roles in development, growth, and homeostasis. N-Cor-mediated transcriptional repression is facilitated through the formation of histone deacetylase (HDACs) N-CoR complexes or by conjugation from small ubiquitin-like modifier 1 (SUMO-1). It is shown that the SANT1 domain of N-CoR serves as a binding region for SUMO-E2 conjugating enzyme Ubc9 and SUMO-E3 ligase Pias1, which is necessary for N-CoR-mediated repression of respective reporter genes. SUMOylation-deficient N-COR knockout mice display a signification reduction in the repression of gene transcription and result in defects involving the differentiation and development of neural cells into erythrocytes and thymocytes. 产品信息 格式 Affinity Purified 控制 - RAW 264.7 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-N-CoR Antibody is a Rabbit Polyclonal Antibody for detection of N-CoR also known as Nuclear receptor corepressor 1 & has been validated in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to a region between amino acids 1510 and 1540 of the N-CoR protein. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_035438
基因符号 - Rxrip13
- Ncor1
纯化方法 Affinity purified UniProt编号 - Q60974.
UniProt汇总 FUNCTION: Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.
SUBUNIT STRUCTURE: Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with TRIM28 and KDM3A. Interacts (via the RD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. Interacts with HEXIM1 By similarity. Interacts with C1D, SIAH2, HDAC7, SAP30, SIN3A and SIN3B. Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is facilitated with RARA trimethylation. Interacts with DACH1. Component of the N-Cor repressor complex, at least composed of CBFA2T3, HEXIM1, NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2.
SUBCELLULAR LOCATION: Nucleus.产品使用声明 质量保证 Evaluated by Western Blot in RAW 264.7 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected N-CoR in RAW 264.7 cell lysate. No tween for best results.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,ECM534,β Integrin-mediated Cell Adhesion Array Kit, fluorimetric
下一件merck millipore产品：merck millipore,默克密理博,CBL1506,Anti-CD4 Antibody, clone OX-38
相关产品
merck millipore,默克密理博,17-245,Acetyl-Histone H3 Immunoprecipitation (ChIP) Assay Kit
merck millipore,默克密理博,AB1058-K,Goat Anti-Influenza B (1mL)
merck millipore,默克密理博,MABE328,Anti-MeCP2 Antibody, clone 4H7
merck millipore,默克密理博,07-476,Anti-p75NTR (Neurotrophin Receptor) Antibody
merck millipore,默克密理博,ECM534,β Integrin-mediated Cell Adhesion Array Kit, fluorimetric
merck millipore,默克密理博,CBL1506,Anti-CD4 Antibody, clone OX-38
merck millipore,默克密理博,07-865,Anti-phospho-PED/PEA-15 (Ser116) Antibody
merck millipore,默克密理博,HTS117RTA,Ready-to-Assay™ M4 Acetylcholine (Muscarinic) Receptor Frozen Cells
merck millipore,默克密理博,SCR011,B6-White™ Murine ES Cell Line
merck millipore,默克密理博,566405,Smad3 Inhibitor, SIS3 - CAS 1009104-85-1 - Calbiochem