merck millipore,默克密理愽
  • merck millipore,默克密理博,07-476,Anti-p75NTR (Neurotrophin Receptor) Antibody

  • merck millipore,默克密理博,07-476,Anti-p75NTR (Neurotrophin Receptor) Antibody

    产品名称：Anti-p75NTR (Neurotrophin Receptor) Antibody
    产品型号：07-476
    Detect p75NTR (Neurotrophin Receptor) using this Anti-p75NTR (Neurotrophin Receptor) Antibody validated for use in IH, IP & WB.

    merck millipore,默克密理博,07-476,Anti-p75NTR (Neurotrophin Receptor) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-476,Anti-p75NTR (Neurotrophin Receptor) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, H, RWB, IHCRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-476
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-p75NTR (Neurotrophin Receptor) Antibody
    Alternate Names
    • p75 ICD
    • CD271 antigen
    • Low affinity neurotrophin receptor p75NTR
    • Low-affinity nerve growth factor receptor
    • NGF receptor
    • low affinity nerve growth factor receptor
    • nerve growth factor receptor
    • nerve growth factor receptor (TNFR superfamily, member 16)
    • member 16)
    背景信息 The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate.
    The neurotrophins are comprised of four proteins, all of which bind to the LNGFR: Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor (BDNF), Neurotrophin-3 (NT-3), and Neurotrophin-4 (NT-4).
    Nerve growth factor, the prototypical growth factor, is a protein secreted by a neuron's target. NGF is critical for the survival and maintenance of sympathetic and sensory neurons. NGF is released from the target cells, binds to and activates its high affinity receptor (TrkA), and is internalized into the responsive neuron. The NGF/TrkA complex is subsequently trafficked back to the cell body. This movement of NGF from axon tip to soma is thought to be involved in the long-distance signaling of neurons.
    产品信息
    格式 Purified
    控制
    • Brain tissue.
    演示 Purified rabbit polyclonal IgG in buffer containing 70% storage buffer 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide and 30% glycerol.
    应用
    应用 Detect p75NTR (Neurotrophin Receptor) using this Anti-p75NTR (Neurotrophin Receptor) Antibody validated for use in IH, IP & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunoprecipitation:
    This antibody has been reported by an independent laboratory to immunoprecipitate p75 neurotrophin receptor.

    Immunohistochemistry:
    This antibody has been reported by an independent laboratory to detect p75 neurotrophin receptor in rat brain sections. (Roux, P., 1999)
    生物信息
    免疫原品种 GST fusion protein corresponding to the intracellular domain (residues 274-425) of rat p75 neurotrophin receptor.
    表位 IC domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes p75 neurotrophin receptor, MW ~75 kDa.
    同种型 IgG
    品种反应性 MouseHumanRat
    Species Reactivity Note Human, mouse, and rat.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_005028.4
    Entrez基因汇总 Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
    基因符号
    • TNFRSF16
    • NGFR
    • Gp80-LNGFR
    • CD271
    • p75(NTR)
    纯化方法 Protein A purfied
    UniProt编号
    • Q53EW1
    UniProt汇总 FUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
    SIZE: 427 amino acids; 45183 Da
    SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9.
    PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues.
    SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats.
    产品使用声明
    质量保证 Evaluated by western blot in RIPA lysates from PC-12 cells.

    Western Blot Analysis:
    0.1-0.5 µg/mL of this antibody detected p75 neurotrophin receptor in RIPA lysates from PC-12 cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20ºC from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-476,Anti-p75NTR (Neurotrophin Receptor) Antibody

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