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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R IHC, FC M Purified Monoclonal Antibody 描述 产品目录编号 CBL1506 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CD4 Antibody, clone OX-38 产品信息 格式 Purified 演示 The monoclonal is presented as 0.5mg/1 mL in phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 应用 This Anti-CD4 Antibody, clone OX-38 is validated for use in FC, IH for the detection of CD4. 主要应用 - Immunohistochemistry
- Flow Cytometry
应用说明 Flow cytometry.
The study of phenotypes of T cells mediating various T cell functions.
Suitable for use on frozen tissue sections and on formalin -fixed paraffin wax embedded tissues.
Optimal working dilutions must be determined by the end user.生物信息 克隆 OX-38 宿主 Mouse 特异性 This antibody detects the CD4 antigen present on a subset of T cells that has suppressor and cytotoxic activities. 90% of thymocytes and NK cells are labelled with this antigen. OX-38 antibody binds to the same epitope of CD4 as the clone W3/25 which differs from the CD4 epitope recognized by OX-35 同种型 IgG2a 品种反应性 Rat 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000616.3
基因符号 - CD4mut
- CD4
UniProt编号 - P01730
UniProt汇总 FUNCTION: SwissProt: P01730 # Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
SIZE: 458 amino acids; 51111 Da
SUBUNIT: Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
PTM: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
SIMILARITY: SwissProt: P01730 ## Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.
MISCELLANEOUS: Primary receptor for HIV-1.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C. 包装信息 数量 500 µg
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