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品种反应性 主要应用 宿主 格式 抗体类型 H, M IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB2283 描述 Anti-Tbr2 Antibody Alternate Names - t box, brain, 2
- eomesodermin (Xenopus laevis) homolog
- eomesodermin homolog (Xenopus laevis)
背景信息 Tbr2 (a T-domain transcription factor) is a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Trb2 has been shown to play a role in the development of the neocortex and functions in the differentiation pathway of radial glia to postmitotic projection neuron. 产品信息 格式 Affinity Purified 控制 - Human Brain Tissue
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 This Anti-Tbr2 Antibody is validated for use in IH for the detection of Tbr2. 主要应用 - Immunohistochemistry
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to mouse Tbr2. 表位 Internal Domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Tbr2. 品种反应性 HumanMouse Species Reactivity Note Proven to react with human and mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_034266
基因符号 - tbr1
- eomes
- TBR2
- eomesodermin
纯化方法 Affinity Purfied UniProt编号 - O54839
UniProt汇总 FUNCTION: Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.
SUBCELLULAR LOCATION: Nucleus Probable.
TISSUE SPECIFICTY: Expressed in CD8+ T-cells.
DEVELOPMENTAL STAGE: Originally expressed in the trophoectoderm of the blastocyst and later in the extra-embryonic ectoderm of the early post-implantation embryo. In the embryo proper, expressed in the posterior part of the epiblast. During gastrulation, extends distally into the primitive streak and nascent mesoderm. Also expressed in the developing forebrain and the olfactory lobes. Expressed at E12.5 and E14.5 in the forebrain.
INDUCTION: Up-regulated in CD8+ T-cells upon activation.
DISRUPTION PHENOTYPE: Embryonic lethal due to peri-implantation defects. Mutant embryos arrest soon after implantation and fail to form organized embryonic or extraembryonic structures. Conditional mutants, with expression abrogated in the inner cell mass of embryos from early implantation stages onward, display gastrulation defects.
SEQUENCE SIMLARITIES: Contains 1 T-box DNA-binding domain.产品使用声明 质量保证 Evaluated by Immunohistochemistry of human brain tissue.
Immunohistochemistry Analysis: A 1:300 dilution of Anti-Tbr2 antibody from a previous lot detected Tbr2 in mouse and human brain tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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