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merck millipore,默克密理博,528283,Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem
产品名称：Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem
产品型号：528283
The Polo-like Kinase Inhibitor II, BTO-1, also referenced under CAS 40647-02-7, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylatio More>>
merck millipore,默克密理博,528283,Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₉H₄N₄O₄S 40647-02-7 描述 概述 A cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays (IC50 = 8.0 µM) and suppress the phosphorylation of cellular Plk1 substrate Cdc25C in rat kangaroo kidney-derived PTK cells (75% inhibition at 6.3 µM). BTO-1 treatment of cultured cells results in mitosis defects consistent with loss-of-Plk1 phenotypes seen in Plk1 RNAi-treated U20S cells, including the appearance of monopolar spindles and the reduction of γ-tubulin at the centrosomes. Plk1 inhibition by BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring. 产品目录编号 528283 品牌系列 Calbiochem®
同义词 5-Cyano-7-nitro-2-(benzothiazolo-N-oxide)-carboxamide 参考 参考 Brennan, I.M., et al. 2007. PloS ONE 2, e409.
Peters, U., et al. 2006. Nat. Chem. Biol. 2, 618.
McInnes, C., et al. 2006. Nat. Chem. Biol. 2, 608.产品信息 CAS号 40647-02-7 形式 Beige solid Hill配方 C₉H₄N₄O₄S 化学配方 C₉H₄N₄O₄S Molar Mass 264.2 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO 安全信息 R相 R: 20/21/22-36/37/38
Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.S相 S: 26-36/37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing and gloves.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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