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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-709 品牌系列 Upstate
商名 - Upstate
描述 Anti-SMC4/hCAP-C Antibody 概述 SMC2 and SMC4 from the active ATPase subunit of Condensin I and Condensin II complexes that regulate chromosome compaction. 产品信息 格式 Serum 应用 应用 Detect SMC4/hCAP-C with Anti-SMC4/hCAP-C Antibody (Rabbit Polyclonal Antibody), that has been shown to work in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated, synthetic peptide corresponding to amino acids 1275-1288 (VAVNPKEIASKGLC) of human SMC4/hCAP-C (Structural maintenance of chromosomes 4/ Chromosome-associated polypeptide C. Immunizing sequence is 100% identical in rat and shares 13/14 identical amino acids in mouse. 宿主 Rabbit 特异性 SMC4/hCAP-C 品种反应性 Human Species Reactivity Note Predicted to cross-react with rat based on sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005496.3
- NM_001002799.1
- NM_001002800.1
基因符号 - CAP-C
- SMC4
- SMC4L1
- CAPC
- hCAP-C
纯化方法 Serum UniProt编号 - Q9NTJ3
UniProt汇总 FUNCTION: SwissProt: Q9NTJ3 # Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
SIZE: 1288 amino acids; 147182 Da
SUBUNIT: Forms an heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.TISSUE SPECIFICITY: Widely expressed. Higher expression in testis, colon, thymus.DOMAIN:SwissProt: Q9NTJ3 The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC2, forming a V-shaped heterodimer (By similarity).
SIMILARITY: Belongs to the SMC family. SMC4 subfamily.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µL
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