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经验配方 C₂₂H₁₈N₄O₂ 描述 概述 A cell-permeable pyridinecarbonitrile compound that acts as a potent, ATP-competitive (Ki = 79 nM, using PKCθ KD in coupled PK/LDH assays), and isozyme-selective PKCθ inhibitor (IC50 = 70 nM) with much reduced potency against other novel PKCs (IC50 = 0.35, 2.33, and 16.35 µM against δ, ε, and η isoforms, respectively) and little or no activity against the conventional PKCβ and atypical PKCζ (IC50 >50 µM) as well as a panel of 18 other commonly studied cellular kinases (IC50 >10 µM). Shown to preferentially inhibit IL-2 production from anti-CD3- and anti-CD28-activated T cells derived from wild-type over PKCθ-knockout mice (IC50 = 58 and 231 nM, respectively). 产品目录编号 539649 品牌系列 Calbiochem®
同义词 5-(3,4-Dimethoxyphenyl)-4-(1H-indol-5-ylamino)-3-pyridinecarbonitrile 参考 参考 Cole, D.C., et al. 2008. J. Med. Chem. 51, 5958. 产品信息 形式 Light yellow powder Hill配方 C₂₂H₁₈N₄O₂ 化学配方 C₂₂H₁₈N₄O₂ Molar Mass 370.4 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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