merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1163,Anti-c-Kit Antibody, clone KIT4

  • merck millipore,默克密理博,MAB1163,Anti-c-Kit Antibody, clone KIT4

    产品名称：Anti-c-Kit Antibody, clone KIT4
    产品型号：MAB1163
    Detect c-Kit using this Anti-c-Kit Antibody, clone KIT4 validated for use in FC, IF & IP.

    merck millipore,默克密理博,MAB1163,Anti-c-Kit Antibody, clone KIT4

  • 产品介绍
  • merck millipore,默克密理博,MAB1163,Anti-c-Kit Antibody, clone KIT4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1163
    Replaces 04-214
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-c-Kit Antibody, clone KIT4
    Alternate Names
    • SCF Receptor
    • CD117
    产品信息
    格式 Purified
    演示 Purified Immunoglobulin. Liquid in 0.02M phosphate buffer with 0.25 M NaCl, pH=7.6 with 0.1% sodium Azide added as a preservative.
    应用
    应用 Detect c-Kit using this Anti-c-Kit Antibody, clone KIT4 validated for use in FC, IF & IP.
    主要应用
    • Flow Cytometry
    应用说明 Flow Cytometry: 1 μg/test (100 μL)

    Immunofluorescence

    Immunoprecipitation; good binding to immobilized Protein A (Caruana, 1999)

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Human megakaryoblastic leukemia cells
    克隆 KIT4
    宿主 Mouse
    特异性 Recognizes c-Kit (CD117, Steel factor receptor, and stem cell factor receptor), a transmembrane receptor tyrosine kinase expressed by hematopoietic progenitor cell subsets and mast cells. The interaction of c-Kit and its ligand is required for normal hematopoiesis, mast cell differentiation, melanogenesis, and gametogenesis. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism.
    同种型 IgG2a
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001093772.1
    • NM_000222.2
    Entrez基因汇总 This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • EC 2.7.10.1
    • KIT
    • C-Kit
    • PBT
    • CD117
    • SCFR
    • c-kit
    UniProt编号
    • P10721
    UniProt汇总 FUNCTION: SwissProt: P10721 # This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K).
    SIZE: 976 amino acids; 109865 Da
    SUBUNIT: Interacts with APS. Interacts with the tenth PDZ domain of MPDZ.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DISEASE: SwissProt: P10721 # Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. & Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764]. & Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).
    SIMILARITY: SwissProt: P10721 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1163,Anti-c-Kit Antibody, clone KIT4

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