- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M ICC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-571 品牌系列 Upstate
商名 - Upstate
描述 Anti-nNOS/NOS I Antibody 概述 Note: ADMA (Catalog #19-169) and NMMA (Catalog #19-170) are inhibitors of NOS 产品信息 格式 Serum 演示 0.05% sodium azide 应用 应用 Anti-nNOS/NOS I Antibody is an antibody against nNOS/NOS I for use in WB & IC. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 Synthetic peptide corresponding to N-terminus of rat nNOS 宿主 Rabbit 特异性 nNOS 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000620
基因符号 - NOS
- NOS1
- bNOS
- nNOS
- N-NOS
- IHPS1
- NC-NOS
纯化方法 Antiserum UniProt编号 - P29475
UniProt汇总 FUNCTION: SwissProt: P29475 # Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter.
COFACTOR: Heme group. & Binds 1 FAD. & Binds 1 FMN. & Metrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
SIZE: 1434 amino acids; 160970 Da
SUBUNIT: Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity).
SUBCELLULAR LOCATION: Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine (By similarity). Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).
TISSUE SPECIFICITY: Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.
DOMAIN: SwissProt: P29475 The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles (By similarity).
DISEASE: SwissProt: P29475 # Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1 (IHPS1) [MIM:179010]. IHPS has an incidence of 1-5 per 1'000 live births in whites and a marked preponderance of males to females (4:1). IHPS is the most frequent disorder requiring surgery in the first year of life. The disorder is characterized by hypertrophy and hyperplasia of the circular muscle layer of the pylorus, leading to persistent vomiting 2-12 weeks after birth. Defective pyloric relaxation and increased pyloric smooth muscle mass have been suggested to be responsible for gastric-outlet obstruction.
SIMILARITY: Belongs to the NOS family. & Contains 1 flavodoxin-like domain. & Contains 1 PDZ (DHR) domain.产品使用声明 质量保证 routinely evaluated by immunoblot in a rat brain microsomal preparation 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µL
上一件merck millipore产品：merck millipore,默克密理博,07-1496,Anti-CaM Kinase II Antibody
下一件merck millipore产品：merck millipore,默克密理博,05-786,Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5
相关产品
merck millipore,默克密理博,MABE192,Anti-hnRNP-P2 Antibody, clone LHC7.15
merck millipore,默克密理博,MAB8186,Anti-EBV EA-D-p52/50 Antibody, clone R3
merck millipore,默克密理博,370653,PknG Inhibitor - CAS 329221-38-7 - Calbiochem
merck millipore,默克密理博,CBL150,Anti-CD3 Antibody, clone UCHT1
merck millipore,默克密理博,07-1496,Anti-CaM Kinase II Antibody
merck millipore,默克密理博,05-786,Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5
merck millipore,默克密理博,529579,PP1 Analog - CAS 221243-82-9 - Calbiochem
merck millipore,默克密理博,12-532,SRPKtide
merck millipore,默克密理博,14-584,PAK4 Protein, active, 10 µg
merck millipore,默克密理博,569744,StemSelect Small Molecule Regulators 384-Well Library I - Calbiochem