merck millipore,默克密理博,14-584,PAK4 Protein, active, 10 µg

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merck millipore,默克密理博,14-584,PAK4 Protein, active, 10 µg
产品名称：PAK4 Protein, active, 10 µg
产品型号：14-584
Active, N-terminal His6 & N-terminal GST-tagged, recombinant, human PAK4 amino acids 295-end, for use in Kinase Assays.

merck millipore,默克密理博,14-584,PAK4 Protein, active, 10 µg

产品介绍

merck millipore,默克密理博,14-584,PAK4 Protein, active, 10 µg

描述
产品目录编号	14-584
品牌系列	Upstate
商名	Upstate
描述	PAK4 Protein, active, 10 µg
概述	expressed by baculovirus in Sf21 cells

应用
应用	Active, N-terminal His6 & N-terminal GST-tagged, recombinant, human PAK4 amino acids 295-end, for use in Kinase Assays.
主要应用	Kinase Assay

生物信息
来源	N-terminal His6 and N-terminal GST-tagged, recombinant, human PAK4 amino acids 295-end
品种	Human
特异活性	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez基因编号	NM_005884.3 NM_001014833.1 NM_001014831.2 NM_001014832.1 NM_001014834.2 NM_001014835.1
Entrez基因汇总	PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
基因符号	KIAA1142 PAK4 PAK-4
蛋白靶	PAK4
纯化方法	Glutathione agarose affinity chromatography
靶子系列	STE
UniProt编号	O96013
UniProt汇总	FUNCTION: SwissProt: O96013 # Activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. SIZE: 591 amino acids; 64072 Da SUBUNIT: Interacts with FGFR2 and GRB2 (By similarity). Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and weakly with RAC1. TISSUE SPECIFICITY: Highest expression in prostate, testis and colon. PTM: Autophosphorylated on serine residues when activated by CDC42/p21. & Phosphorylated on tyrosine residues upon stimulation of FGFR2 (By similarity). SIMILARITY: SwissProt: O96013 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.

产品使用声明
质量保证	routinely evaluated by phosphorylation of MBP (Catalog #13-104)
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	6 months at -70°C

包装信息
数量	10 µg
包装	Also available in 250 µg size --call for pricing and availability and reference catalog number 14-584M when ordering the 250 µg size.

merck millipore,默克密理博,14-584,PAK4 Protein, active, 10 µg

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