merck millipore,默克密理愽
  • merck millipore,默克密理博,07-330,Anti-Partitioning-defective 3 Antibody

  • merck millipore,默克密理博,07-330,Anti-Partitioning-defective 3 Antibody

    产品名称：Anti-Partitioning-defective 3 Antibody
    产品型号：07-330
    Anti-Partitioning-defective 3 Antibody is an antibody against Partitioning-defective 3 for use in IC & WB.

    merck millipore,默克密理博,07-330,Anti-Partitioning-defective 3 Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-330,Anti-Partitioning-defective 3 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Ca, H, R, Mk, MWB, ICCRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-330
    Replaces MABS174
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Partitioning-defective 3 Antibody
    Alternate Names
    • partitioning-defective protein 3 homolog
    • Atypical PKC isotype-specific-interacting protein
    • CTCL tumor antigen se2-5
    • atypical PKC isotype-specific interacting protein
    • par-3 (partitioning defective 3, C.elegans) homolog
    • par-3 partitioning defective 3 homolog (C. elegans)
    • par-3 partitioning defective 3 homolog (C. elegans)
    背景信息 PAR3 is an adapter protein involved in asymmetrical cell division and cell polarization processes. It seems to play a central role in the formation of epithelial tight junctions. Its association with PARD6B may prevent the interaction of PAR3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PAR3 complex links GTP bound Rho small GTPases to atypical protein kinase C proteins. PAR3 interacts with PARD6A and PARD6B. Isoform 2, but not at least isoform 3 interacts with PRKCZ. PAR3 interacts with PRCKI. PAR3 forms part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. PAR3 interacts with F11R/JAM1. Antibodies against PAR3 are present in sera from patients with cutaneous T cell lymphomas.
    产品信息
    格式 Purified
    控制
    • 3T3/A31 lysate.

      Included Positive Antigen Control: Catalog # 12-305, 3T3/A31 lysate. Add 2.5 µL of 2-mercapto-ethanol/100 µL of lysate and boil for 5 minutes to reduce the preparation. Load 20 µg of reduced lysate per lane for minigels.
    演示 Purified rabbit polyclonal in buffer containing 0.014 M phosphate buffer, pH 7.6, 0.175 M NaCl, 0.07% sodium azide and 30% glycerol.
    应用
    应用 Anti-Partitioning-defective 3 Antibody is an antibody against Partitioning-defective 3 for use in IC & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    应用说明 Immunocytochemistry:
    A previous lot of this antibody showed positive immunostaining for PAR-3 in MDCK cells fixed with 3% paraformaldehyde followed by permeabilization with 0.1% Triton X-100 has been shown by an independent laboratory.
    生物信息
    免疫原品种 GST fusion protein corresponding to residues 457-744 of mouse PAR-3 (accession number AY02657).
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes all 3 slice isoforms of PAR-3, MW ~180, 150, 100 kDa.
    同种型 IgG
    品种反应性 CanineHumanRatMonkeyMouse
    Species Reactivity Note Mouse, human, rat, monkey and canine.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_062565
    Entrez基因汇总 PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins (GAPs; see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.[supplied by OMIM]
    基因符号
    • SE2-5LT1
    • PAR3
    • PARD3
    • ASIP
    • PHIP
    • SE2-5T2
    • PAR-3
    • SE2-5L16
    • PARD-3
    • PARD3A
    • PAR3A
    • PAR3alpha
    • PAR3-alpha
    • Bazooka
    • FLJ21015
    • Baz
    纯化方法 Protein A chromatography
    UniProt编号
    • Q8TEW0
    UniProt汇总 FUNCTION: SwissProt: Q8TEW0 # Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
    SIZE: 1356 amino acids; 151423 Da
    SUBUNIT: Interacts with PARD6A and PARD6B. Isoform 2, but not at least isoform 3 interacts with PRKCZ. Interacts with PRCKI (By similarity). Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. Interacts with F11R/JAM1 (By similarity). Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3.
    SUBCELLULAR LOCATION: Intracytoplasmic membrane. Cell junction. Cell membrane. Note=Partially localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions.
    TISSUE SPECIFICITY: Widely expressed.
    PTM: Phosphorylated by PRKCZ.
    SIMILARITY: SwissProt: Q8TEW0 ## Belongs to the PAR3 family. & Contains 3 PDZ (DHR) domains.
    MISCELLANEOUS: Antibodies against PARD3 are present in sera from patients with cutaneous T-cell lymphomas.
    产品使用声明
    质量保证 Evaluated by western blot on RIPA lysates from 3T3/A31, A431, and HeLa cells.

    Western Blot Analysis:
    0.5-2 µg/mL of this antibody detected PAR-3 isoforms in RIPA lysates from 3T3/A31, A431, and HeLa cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20ºC from date of receipt.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,07-330,Anti-Partitioning-defective 3 Antibody

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