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品种反应性 主要应用 宿主 格式 抗体类型 H FC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABF133 描述 Anti-PD-L1 Antibody/CD274 Alternate Names - CD274
- Programmed cell death 1 ligand 1
- PD-L1
- PDCD1 ligand 1
- Programmed death ligand 1
- B7 homolog 1
- B7-H1
背景信息 Programmed cell death 1 ligand 1 (PD-L1/CD274) is a B7 related protein belonging to the BTN/MOG family. PDL-1/CD274 is essential for T-cell proliferation and production of IL10 and IFNG. PD-L1/CD274 reduces the secretion of IL-2 and IL-10 from memory T cells by inhibiting cell-mediated immune responses. PD-L1/CD274 may be involved in reducing allogenic CD4+ memory T-cell responses to endothelial cells. PD-L1/CD274 is highly expressed in heart, skeletal muscle, placenta, and lung and weakly expressed in thymus, spleen, kidney, and liver. 产品信息 格式 Affinity Purified 演示 Purified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-PD-L1 Antibody/CD274 is an antibody against PD-L1/CD274 for use in western blotting & flow cytometry. 主要应用 - Flow Cytometry
- Western Blotting
应用说明 Western Blotting Analysis: 2 µg/mL from a representative lot detected PD-L1/CD274 in 10 µg of K562 cell lysate.
Flow Cytometry Analysis: 0.25 µg from a representative lot detected PD-L1/CD274 in 1X10E6 K562 cells.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the extracellular domain of human PD-L1/CD274. 表位 This antibody recognizes the Ig-like C2-type domain in the extracellular domain of PD-L1/CD274. 浓缩 1 mg/mL 宿主 Rabbit 特异性 This antibody should recognize isoforms 1 and 2 based upon immunogen design. 品种反应性 Human Species Reactivity Note Human. Predicted to react with Rhesus Macaque based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_054862
基因符号 - PDL1
- CD274
- B7H1
- PDCD1L1
- PDCD1LG1
纯化方法 Affinity purified UniProt编号 - Q9NZQ7
产品使用声明 质量保证 Evaluated by Western Blotting in Jurkat cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected PD-L1/CD274 in 10 µg of Jurkat cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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